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Query: DICER1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DICER1 1 1.707 -0.810 0.800 1.748 -0.207 -0.634

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for DICER1:


Pubmed-DICER1 »
Uniprot-DICER1 »
Biogrid-DICER1 »
ProteomicsDB-DICER1 »

Tumorportal-DICER1 »
COSMIC-DICER1 »
GenomeRNAi-DICER1 »
Genecards-DICER1


Protein-protein Interactions for DICER1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait DICER1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF2C2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF2C3 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAP1B Cat. description Hein, Mann, Cell 2015
Category members IP bait SGTB Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait TIMM13 Cat. description Hein, Mann, Cell 2015
Category members IP bait USF1;usf1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAMTS4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBXL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXD4L6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1683 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNKD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STRBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRMT2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DICER1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Helicase/UvrB_dom IPR006935 0.78
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members dsRNA-bd_dom IPR014720 0.23
Category members PAZ_dom IPR003100 0.15
Category members RNase_III_dom IPR000999 0


Protein complexes (CORUM database) featuring DICER1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5380 TRBP containing complex (DICER, RPL7A, EIF6, MOV10 and subunits of the 60S ribosomal particle) Database 5.3
Category members Corum 1385 DICER1-NCOA6-AGO2 complex Database 0
Category members Corum 3032 RNA-induced silencing complex, RISC Database 0
Category members Corum 5377 RNA-induced silencing complex, RISC Database 0
Category members Corum 5378 TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10) Database 0
Category members Corum 5381 RNA-induced silencing complex, RISC Database 0


Categories featuring DICER1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0030426 growth cone Database 1.61
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Database 0.74
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_208 PID_TAP63_PATHWAY 0 0.52
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0051225 spindle assembly Database 0.25
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members Pathway Pathway_368 REACTOME_MICRORNA_MIRNA_BIOGENESIS 0 0.18
Category members GO Category GO:0016442 RISC complex Database 0.18
Category members GO Category GO:0006396 RNA processing Database 0.17
Category members GO Category GO:0050767 regulation of neurogenesis Database 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_379 REACTOME_REGULATORY_RNA_PATHWAYS 0 0.12
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members GO Category GO:0031643 positive regulation of myelination Database 0.08
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0031069 hair follicle morphogenesis Database 0.06
Category members GO Category GO:0045069 regulation of viral genome replication Database 0.05
Category members GO Category GO:0014040 positive regulation of Schwann cell differentiation Database 0.04
Category members GO Category GO:0035264 multicellular organism growth Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0031054 pre-miRNA processing Database 0.01
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0004525 ribonuclease III activity Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0010070 zygote asymmetric cell division Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0010626 negative regulation of Schwann cell proliferation Database 0
Category members GO Category GO:0010628 positive regulation of gene expression Database 0
Category members GO Category GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters Database 0
Category members GO Category GO:0021522 spinal cord motor neuron differentiation Database 0
Category members GO Category GO:0021675 nerve development Database 0
Category members GO Category GO:0021889 olfactory bulb interneuron differentiation Database 0
Category members GO Category GO:0030326 embryonic limb morphogenesis Database 0
Category members GO Category GO:0030422 production of siRNA involved in RNA interference Database 0
Category members GO Category GO:0030423 targeting of mRNA for destruction involved in RNA interference Database 0
Category members GO Category GO:0031641 regulation of myelination Database 0
Category members GO Category GO:0032290 peripheral nervous system myelin formation Database 0
Category members GO Category GO:0035116 embryonic hindlimb morphogenesis Database 0
Category members GO Category GO:0035196 production of miRNAs involved in gene silencing by miRNA Database 0
Category members GO Category GO:0035198 miRNA binding Database 0
Category members GO Category GO:0042487 regulation of odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0045595 regulation of cell differentiation Database 0
Category members GO Category GO:0045664 regulation of neuron differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048536 spleen development Database 0
Category members GO Category GO:0048565 digestive tract development Database 0
Category members GO Category GO:0048713 regulation of oligodendrocyte differentiation Database 0
Category members GO Category GO:0048730 epidermis morphogenesis Database 0
Category members GO Category GO:0048754 branching morphogenesis of an epithelial tube Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0055013 cardiac muscle cell development Database 0
Category members GO Category GO:0060119 inner ear receptor cell development Database 0
Category members GO Category GO:0060576 intestinal epithelial cell development Database 0
Category members GO Category GO:0070173 regulation of enamel mineralization Database 0


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