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Query: CHD8

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
CHD8 1 4.653 -1.310 2.760 -1.168 0.026 0.297
CHD8 1 4.653 -1.310 2.760 -0.896 0.435 0.478 -1.819 -1.191

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
CHD8 Phosphorylation S2046 0.427 0.449 _VS(ph)PSDTTPLVSR_
CHD8 Phosphorylation S1978 0.606 0.061 _M(ox)NYM(ox)QNHQAGAPAPSLS(ph)R_
CHD8 Phosphorylation S1874 -0.088 -0.155 _TPFKDEIDEFANS(ph)PSEDKEESMEIHATGK_
CHD8 Phosphorylation S2956 0.383 -0.248 _DGETLEGS(ph)DAEESLDK_
CHD8 Phosphorylation S557 -0.452 _VPVHQHS(ph)PSEPFLEKPVPDM(ox)TQVSGPNAQLVK_
CHD8 Phosphorylation S2559 -0.345 -0.513 _NIPS(ph)PGQLDPDTR_
CHD8 Phosphorylation S2519 -0.083 -0.552 _APGYPSS(ph)PVTTASGTTLR_
CHD8 Phosphorylation S2533 -0.792 _RTS(ph)LSAEDAEVTK_
CHD8 Phosphorylation S1995 -0.690 -1.351 _TAS(ph)PLPLRPDAPVEK_
CHD8 Phosphorylation T1993 -1.383 -1.407 _T(ph)ASPLPLRPDAPVEKS(ph)PEETATQVPSLESLTLK_
CHD8 Phosphorylation S2008 -1.339 -1.407 _T(ph)ASPLPLRPDAPVEKS(ph)PEETATQVPSLESLTLK_
CHD8 Ubiquitylation K1766 0.498 _EQMK(gl)IEAAER_

Background Information for CHD8:


Pubmed-CHD8 »
Uniprot-CHD8 »
Biogrid-CHD8 »
ProteomicsDB-CHD8 »

Tumorportal-CHD8 »
COSMIC-CHD8 »
GenomeRNAi-CHD8 »
Genecards-CHD8


Protein-protein Interactions for CHD8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHD8 Cat. description Hein, Mann, Cell 2015
Category members IP bait GTF2B Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KPNB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MSH6 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAB4B Cat. description Hein, Mann, Cell 2015
Category members IP bait SNAP29 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBGCP4 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CARD8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFATC2IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDH20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIP4K2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSME3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFPL4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SPINT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBL1Y Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait YAF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in CHD8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members Chromo_domain/shadow IPR000953 2.84
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members Chromodomain-like IPR016197 2.29
Category members Chromo_domain IPR023780 1.98
Category members Helicase/UvrB_dom IPR006935 0.78
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members BRK_domain IPR006576 0


Protein complexes (CORUM database) featuring CHD8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5386 MLL1-WDR5 complex Database 0.31


Categories featuring CHD8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0003678 DNA helicase activity Database 2.22
Category members GO Category GO:0002039 p53 binding Database 2.06
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0043044 ATP-dependent chromatin remodeling Database 1.41
Category members GO Category GO:0032508 DNA duplex unwinding Database 1.24
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042393 histone binding Database 0.94
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0035064 methylated histone residue binding Database 0.53
Category members GO Category GO:0071339 MLL1 complex Database 0.45
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members Pathway Pathway_679 KEGG_WNT_SIGNALING_PATHWAY 0 0.09
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06
Category members Disease phenotype AUTISM AUTISM Database 0
Category members GO Category GO:0030178 negative regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0045945 positive regulation of transcription from RNA polymerase III promoter Database 0
Category members GO Category GO:0060070 canonical Wnt signaling pathway Database 0
Category members GO Category GO:0070016 armadillo repeat domain binding Database 0


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