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Query: AP1S2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AP1S2 0 -1.049 1.190 -0.690 -1.049

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for AP1S2:


Pubmed-AP1S2 »
Uniprot-AP1S2 »
Biogrid-AP1S2 »
ProteomicsDB-AP1S2 »

Tumorportal-AP1S2 »
COSMIC-AP1S2 »
GenomeRNAi-AP1S2 »
Genecards-AP1S2


Protein-protein Interactions for AP1S2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AP1S2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP1M2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAV3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CORT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POTEB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP6R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AP1S2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Longin-like_dom IPR011012 0.34
Category members AP_complex_ssu IPR016635 0.31
Category members AP_mu_sigma_su IPR022775 0.25


Protein complexes (CORUM database) featuring AP1S2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 144 Gamma-BAR-AP1 complex Database 0.03
Category members Corum 36 AP1 adaptor complex Database 0


Categories featuring AP1S2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_195 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS 0 1.08
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_194 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 0 0.83
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0006892 post-Golgi vesicle-mediated transport Database 0.74
Category members GO Category GO:0030659 cytoplasmic vesicle membrane Database 0.62
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0050690 regulation of defense response to virus by virus Database 0.49
Category members Pathway Pathway_1266 REACTOME_NEF_MEDIATED_DOWNREGULATION_OF_MHC_CLASS_I_COMPLEX_CELL_SURFACE_EXPRESSION 0 0.36
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members Pathway Pathway_473 REACTOME_LYSOSOME_VESICLE_BIOGENESIS 0 0.13
Category members GO Category GO:0032588 trans-Golgi network membrane Database 0.05
Category members GO Category GO:0030119 AP-type membrane coat adaptor complex Database 0.03
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0030117 membrane coat Database 0


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