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Query: ACSL4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACSL4 0 0.708 1.120 -0.740 -0.154 -1.054 0.236 0.117

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACSL4 Ubiquitylation K354 0.109 0.988 _IGYSSPLTLSDQSSK(gl)IK_
ACSL4 Ubiquitylation K356 0.153 0.800 _IGYSSPLTLSDQSSKIK(gl)_
ACSL4 Ubiquitylation K661 0.291 0.519 _EAANAM(ox)K(gl)LER_
ACSL4 Ubiquitylation K621 0.455 0.184 _SDQSYVISFVVPNQK(gl)R_
ACSL4 Ubiquitylation K670 -0.058 -0.343 _FEIPIK(gl)VR_
ACSL4 Ubiquitylation K500 -1.017 -0.639 _LK(gl)DWQEGGYTINDKPNPR_
ACSL4 Ubiquitylation K49 -1.745 _AK(gl)PTSDKPGSPYR_
ACSL4 Ubiquitylation K54 -1.457 _AKPTSDK(gl)PGSPYR_
ACSL4 Ubiquitylation K702 0.575 _NHYLK(gl)DIER_

Background Information for ACSL4:


Pubmed-ACSL4 »
Uniprot-ACSL4 »
Biogrid-ACSL4 »
ProteomicsDB-ACSL4 »

Tumorportal-ACSL4 »
COSMIC-ACSL4 »
GenomeRNAi-ACSL4 »
Genecards-ACSL4


Protein-protein Interactions for ACSL4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACSL4 Cat. description Hein, Mann, Cell 2015
Category members IP bait HNRNPD Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP6V0D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EID3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNAT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MME Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC15A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC39A12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC6A15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBC1D22A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TOR1AIP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACSL4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members AMP-dep_Synth/Lig IPR000873 0


Protein complexes (CORUM database) featuring ACSL4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACSL4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_133 KEGG_FATTY_ACID_METABOLISM 0 0.31
Category members Pathway Pathway_1 REACTOME_FATTY_ACID_TRIACYLGLYCEROL_AND_KETONE_BODY_METABOLISM 0 0.23
Category members Pathway Pathway_6 REACTOME_FATTY_ACYL_COA_BIOSYNTHESIS 0 0.2
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0035338 long-chain fatty-acyl-CoA biosynthetic process Database 0.1
Category members Pathway Pathway_2 REACTOME_TRIGLYCERIDE_BIOSYNTHESIS 0 0.08
Category members GO Category GO:0008610 lipid biosynthetic process Database 0.05
Category members Pathway Pathway_152 REACTOME_SYNTHESIS_OF_VERY_LONG_CHAIN_FATTY_ACYL_COAS 0 0.04
Category members GO Category GO:0060136 embryonic process involved in female pregnancy Database 0.04
Category members Disease phenotype X-linked_non-syndromic_intellectual_disability X-linked non-syndromic intellectual disability Database 0.01
Category members GO Category GO:0005778 peroxisomal membrane Database 0.01
Category members Pathway Pathway_25 KEGG_PEROXISOME 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_40 KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_43 KEGG_PPAR_SIGNALING_PATHWAY 0 0
Category members Disease phenotype Alport_syndrome_-_intellectual_disability_-_midface_hypoplasia_-_elliptocytosis Alport syndrome - intellectual disability - midface hypoplasia - elliptocytosis Database 0
Category members Disease phenotype AMME_COMPLEX AMME COMPLEX Database 0
Category members GO Category GO:0001676 long-chain fatty acid metabolic process Database 0
Category members GO Category GO:0004467 long-chain fatty acid-CoA ligase activity Database 0
Category members GO Category GO:0005777 peroxisome Database 0
Category members GO Category GO:0005811 lipid particle Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006641 triglyceride metabolic process Database 0
Category members GO Category GO:0007584 response to nutrient Database 0
Category members GO Category GO:0008152 metabolic process Database 0
Category members GO Category GO:0015908 fatty acid transport Database 0
Category members GO Category GO:0019432 triglyceride biosynthetic process Database 0
Category members GO Category GO:0030307 positive regulation of cell growth Database 0
Category members GO Category GO:0031957 very long-chain fatty acid-CoA ligase activity Database 0
Category members GO Category GO:0031966 mitochondrial membrane Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0044255 cellular lipid metabolic process Database 0
Category members GO Category GO:0060996 dendritic spine development Database 0
Category members GO Category GO:0070672 response to interleukin-15 Database 0


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