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Query: XRN1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XRN1 0 -1.606 1.680 -1.120
XRN1 0 -1.606 1.680 -1.120 -0.304 -0.943 0.164

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XRN1 Phosphorylation S814 -0.523 _ENEVQSSHHGEPPSEEHLS(ph)PQSFAM(ox)K_

Background Information for XRN1:


Pubmed-XRN1 »
Uniprot-XRN1 »
Biogrid-XRN1 »
ProteomicsDB-XRN1 »

Tumorportal-XRN1 »
COSMIC-XRN1 »
GenomeRNAi-XRN1 »
Genecards-XRN1


Protein-protein Interactions for XRN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG6;BAT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA50 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait QSOX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADPRH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NAGK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCRN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XRN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Put_53exo IPR004859 0.29
Category members PIN_domain-like IPR029060 0


Protein complexes (CORUM database) featuring XRN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 822 mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) Database 1.39


Categories featuring XRN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0016075 rRNA catabolic process Database 0.48
Category members Pathway Pathway_844 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 0 0.38
Category members GO Category GO:0071044 histone mRNA catabolic process Database 0.35
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members GO Category GO:0045111 intermediate filament cytoskeleton Database 0.26
Category members GO Category GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Database 0.21
Category members GO Category GO:0071028 nuclear mRNA surveillance Database 0.19
Category members Pathway Pathway_846 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 0 0.18
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members GO Category GO:0008409 5'-3' exonuclease activity Database 0.13
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members GO Category GO:0000956 nuclear-transcribed mRNA catabolic process Database 0.04
Category members Pathway Pathway_843 REACTOME_MRNA_DECAY_BY_5_TO_3_EXORIBONUCLEASE 0 0
Category members GO Category GO:0004527 exonuclease activity Database 0


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