Results for the Category
REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1
(Pathway_844)
| RNAi screen result | RNAPII IP (MG132) | CSB IP | CSB IP (MG132) | Chrom. | Chrom. (MG132) | Ubi /Phospo | Ubi /Phospho (MG132) |
| W | |||||||
| Gene name | MGoogle Score | RNAi high | RNAi low | RNAPII-IP (MG132) | CSB-IP | CSB-IP (MG132) | Chrom. | Chrom. (MG132) |
|---|---|---|---|---|---|---|---|---|
| EXOSC3 | 1 | -1.840 | 3.020 | -0.152 | -0.472 | -0.227 | -0.542 | -0.121 |
| EXOSC8 | 1 | -2.330 | 4.300 | 0.175 | ||||
| EXOSC7 | 0 | 0.320 | 0.360 | 0.498 | -0.198 | 0.040 | 0.896 | -0.129 |
| EXOSC5 | 0 | -1.260 | 2.170 | |||||
| EXOSC5 | 0 | -1.260 | 2.170 | 0.148 | 0.414 | |||
| DIS3 | 0 | 0.150 | -0.690 | |||||
| DIS3 | 0 | 0.150 | -0.690 | -0.335 | -0.438 | -0.111 | ||
| XRN1 | 0 | 1.680 | -1.120 | |||||
| XRN1 | 0 | 1.680 | -1.120 | -0.304 | -0.943 | 0.164 | ||
| EXOSC9 | 0 | 0.080 | 0.519 | 0.128 | -0.495 | 0.107 | ||
| EXOSC2 | 0 | -0.410 | 0.130 | -0.167 | 0.162 | 0.416 | -0.803 | 0.148 |
| AKT1 | 0 | -0.050 | 0.700 | |||||
| AKT1 | 0 | 0.860 | -0.040 | |||||
| YWHAB | 0 | 0.628 | -0.543 | |||||
| YWHAB | 0 | 0.507 | 0.271 | 0.503 | ||||
| EXOSC1 | 0 | -1.320 | 2.040 | -0.540 | -0.773 | -0.524 | ||
| ZFP36L1 | 0 | 1.190 | -0.490 | |||||
| EXOSC6 | 0 | 1.090 | -0.810 | -0.397 | -1.242 | -0.177 |
| Gene name | PTM type | PTM site | UV | UV (MG132) | Sequence |
|---|---|---|---|---|---|
| AKT1 | Phosphorylation | S124 | 0.252 | 0.311 | _SGS(ph)PSDNSGAEEMEVSLAKPK_ |
| AKT1 | Phosphorylation | S126 | -0.241 | _SGSPS(ph)DNSGAEEM(ox)EVSLAK_ | |
| AKT1 | Ubiquitylation | K301 | 0.988 | _EGIK(gl)DGATMK_ | |
| DIS3 | Ubiquitylation | K337 | -0.491 | _TAVSEK(gl)MLKPTGR_ | |
| DIS3 | Ubiquitylation | K535 | -0.201 | _RGTTVYLCEK(gl)R_ | |
| EXOSC2 | Ubiquitylation | K70 | -0.209 | _LICVK(gl)ALK_ | |
| EXOSC2 | Ubiquitylation | K97 | 0.060 | _WK(gl)VETNSR_ | |
| EXOSC2 | Phosphorylation | S175 | -0.346 | -0.185 | _LGQGVLVQVS(ph)PSLVK_ |
| EXOSC2 | Ubiquitylation | K180 | -0.618 | _LGQGVLVQVSPSLVK(gl)R_ | |
| EXOSC5 | Ubiquitylation | K68 | -1.576 | _VSK(gl)EIFNK_ | |
| EXOSC5 | Ubiquitylation | K92 | -1.386 | 0.381 | _IGLPGVAEK(gl)SR_ |
| EXOSC5 | Ubiquitylation | K191 | -0.124 | _K(gl)LLMSSTK_ | |
| EXOSC8 | Ubiquitylation | K6 | -0.039 | -1.840 | _(ac)AAGFK(gl)TVEPLEYYRR_ |
| EXOSC8 | Ubiquitylation | K19 | 0.825 | _FLK(gl)ENCRPDGR_ | |
| EXOSC9 | Ubiquitylation | K52 | 0.195 | _ISFGTDYGCCIVELGK(gl)TR_ | |
| EXOSC9 | Phosphorylation | S306 | 0.254 | 0.180 | _APIDTS(ph)DVEEK_ |
| XRN1 | Phosphorylation | S814 | -0.523 | _ENEVQSSHHGEPPSEEHLS(ph)PQSFAM(ox)K_ | |
| YWHAB | Ubiquitylation | K11 | 1.057 | 1.322 | _(ac)TMDKSELVQK(gl)AK_ |
| YWHAB | Ubiquitylation | K13 | 0.060 | 0.388 | _AK(gl)LAEQAER_ |
| YWHAB | Ubiquitylation | K70 | 0.558 | -0.175 | _VISSIEQK(gl)TER_ |
| YWHAB | Ubiquitylation | K140 | 0.531 | _YLSEVASGDNK(gl)QTTVSNSQQAYQEAFEISKK_ | |
| YWHAB | Ubiquitylation | K159 | 0.300 | _QTTVSNSQQAYQEAFEISK(gl)K_ | |
| YWHAB | Ubiquitylation | K160 | -0.439 | -0.371 | _K(gl)EMQPTHPIR_ |
| ZFP36L1 | Ubiquitylation | K103 | -1.487 | _LLPTQK(gl)QPGGGQVNSSR_ |
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