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Query: DIS3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
DIS3 0 -1.085 0.150 -0.690
DIS3 0 -1.085 0.150 -0.690 -0.335 -0.438 -0.111

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
DIS3 Ubiquitylation K337 -0.491 _TAVSEK(gl)MLKPTGR_
DIS3 Ubiquitylation K535 -0.201 _RGTTVYLCEK(gl)R_

Background Information for DIS3:


Pubmed-DIS3 »
Uniprot-DIS3 »
Biogrid-DIS3 »
ProteomicsDB-DIS3 »

Tumorportal-DIS3 »
COSMIC-DIS3 »
GenomeRNAi-DIS3 »
Genecards-DIS3


Protein-protein Interactions for DIS3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC94 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DCX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLX4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EID3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GAS2L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IQCF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MUS81 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RDBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SERPINB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSBP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF212 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in DIS3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PIN_dom IPR002716 0
Category members PIN_domain-like IPR029060 0


Protein complexes (CORUM database) featuring DIS3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 789 Exosome Database 0.83
Category members Corum 788 Exosome Database 0.5


Categories featuring DIS3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0000178 exosome (RNase complex) Database 0.78
Category members Pathway Pathway_392 REACTOME_PERK_REGULATED_GENE_EXPRESSION 0 0.64
Category members GO Category GO:0071034 CUT catabolic process Database 0.53
Category members GO Category GO:0016075 rRNA catabolic process Database 0.48
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members Pathway Pathway_844 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 0 0.38
Category members Pathway Pathway_848 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE 0 0.35
Category members GO Category GO:0000176 nuclear exosome (RNase complex) Database 0.29
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members Pathway Pathway_391 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 0 0.23
Category members GO Category GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Database 0.21
Category members Pathway Pathway_846 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 0 0.18
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members Pathway Pathway_847 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP 0 0.04
Category members GO Category GO:0000175 3'-5'-exoribonuclease activity Database 0
Category members GO Category GO:0004519 endonuclease activity Database 0
Category members GO Category GO:0005085 guanyl-nucleotide exchange factor activity Database 0


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