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Query: EXOSC5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EXOSC5 0 2.989 -1.260 2.170
EXOSC5 0 2.989 -1.260 2.170 0.148 0.414

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EXOSC5 Ubiquitylation K92 -1.386 0.381 _IGLPGVAEK(gl)SR_
EXOSC5 Ubiquitylation K68 -1.576 _VSK(gl)EIFNK_
EXOSC5 Ubiquitylation K191 -0.124 _K(gl)LLMSSTK_

Background Information for EXOSC5:


Pubmed-EXOSC5 »
Uniprot-EXOSC5 »
Biogrid-EXOSC5 »
ProteomicsDB-EXOSC5 »

Tumorportal-EXOSC5 »
COSMIC-EXOSC5 »
GenomeRNAi-EXOSC5 »
Genecards-EXOSC5


Protein-protein Interactions for EXOSC5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DIS3L Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC1;RP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM7 Cat. description Hein, Mann, Cell 2015
Category members IP bait C1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EXOSC5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members ExoRNase_PH_dom1 IPR001247 0.23
Category members ExoRNase_PH_dom2 IPR015847 0.23


Protein complexes (CORUM database) featuring EXOSC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 789 Exosome Database 0.83
Category members Corum 788 Exosome Database 0.5


Categories featuring EXOSC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0000178 exosome (RNase complex) Database 0.78
Category members Pathway Pathway_392 REACTOME_PERK_REGULATED_GENE_EXPRESSION 0 0.64
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members Pathway Pathway_844 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 0 0.38
Category members Pathway Pathway_848 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE 0 0.35
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members Pathway Pathway_391 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 0 0.23
Category members GO Category GO:0045006 DNA deamination Database 0.23
Category members GO Category GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Database 0.21
Category members Pathway Pathway_846 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 0 0.18
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0035327 transcriptionally active chromatin Database 0.04
Category members Pathway Pathway_847 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP 0 0.04
Category members GO Category GO:0000175 3'-5'-exoribonuclease activity Database 0
Category members GO Category GO:0006401 RNA catabolic process Database 0


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