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Query: EXOSC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EXOSC1 0 0.203 -1.320 2.040 -0.540 -0.773 -0.524

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for EXOSC1:


Pubmed-EXOSC1 »
Uniprot-EXOSC1 »
Biogrid-EXOSC1 »
ProteomicsDB-EXOSC1 »

Tumorportal-EXOSC1 »
COSMIC-EXOSC1 »
GenomeRNAi-EXOSC1 »
Genecards-EXOSC1


Protein-protein Interactions for EXOSC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EXOSC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members NA-bd_OB-fold IPR012340 4.37
Category members S1_dom IPR022967 0.15


Protein complexes (CORUM database) featuring EXOSC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 789 Exosome Database 0.83
Category members Corum 788 Exosome Database 0.5


Categories featuring EXOSC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0000178 exosome (RNase complex) Database 0.78
Category members Pathway Pathway_392 REACTOME_PERK_REGULATED_GENE_EXPRESSION 0 0.64
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members Pathway Pathway_844 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 0 0.38
Category members Pathway Pathway_848 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE 0 0.35
Category members Pathway Pathway_408 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY 0 0.32
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members Pathway Pathway_391 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 0 0.23
Category members GO Category GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Database 0.21
Category members Pathway Pathway_846 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 0 0.18
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members Pathway Pathway_847 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP 0 0.04


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