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Query: EXOSC8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EXOSC8 1 3.460 -2.330 4.300 0.175

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EXOSC8 Ubiquitylation K6 -0.039 -1.840 _(ac)AAGFK(gl)TVEPLEYYRR_
EXOSC8 Ubiquitylation K19 0.825 _FLK(gl)ENCRPDGR_

Background Information for EXOSC8:


Pubmed-EXOSC8 »
Uniprot-EXOSC8 »
Biogrid-EXOSC8 »
ProteomicsDB-EXOSC8 »

Tumorportal-EXOSC8 »
COSMIC-EXOSC8 »
GenomeRNAi-EXOSC8 »
Genecards-EXOSC8


Protein-protein Interactions for EXOSC8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DIS3L Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC1;RP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait EXOSC9 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMPO Cat. description Hein, Mann, Cell 2015
Category members IP bait C1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EXOSC8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EXOSC8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06
Category members ExoRNase_PH_dom1 IPR001247 0.23
Category members ExoRNase_PH_dom2 IPR015847 0.23


Protein complexes (CORUM database) featuring EXOSC8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 789 Exosome Database 0.83
Category members Corum 788 Exosome Database 0.5


Categories featuring EXOSC8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0000178 exosome (RNase complex) Database 0.78
Category members Pathway Pathway_392 REACTOME_PERK_REGULATED_GENE_EXPRESSION 0 0.64
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members Pathway Pathway_844 REACTOME_DESTABILIZATION_OF_MRNA_BY_BRF1 0 0.38
Category members Pathway Pathway_848 REACTOME_MRNA_DECAY_BY_3_TO_5_EXORIBONUCLEASE 0 0.35
Category members Pathway Pathway_310 KEGG_RNA_DEGRADATION 0 0.26
Category members Pathway Pathway_391 REACTOME_ACTIVATION_OF_GENES_BY_ATF4 0 0.23
Category members GO Category GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay Database 0.21
Category members Pathway Pathway_846 REACTOME_DESTABILIZATION_OF_MRNA_BY_TRISTETRAPROLIN_TTP 0 0.18
Category members GO Category GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Database 0.17
Category members Pathway Pathway_842 REACTOME_DEADENYLATION_DEPENDENT_MRNA_DECAY 0 0.1
Category members Pathway Pathway_847 REACTOME_DESTABILIZATION_OF_MRNA_BY_KSRP 0 0.04
Category members GO Category GO:0008150 biological_process Database 0
Category members GO Category GO:0017091 AU-rich element binding Database 0


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