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Query: XRCC5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XRCC5 0 1.886 1.940 -0.800 0.205 -0.587 0.234 -0.176 0.162

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XRCC5 Ubiquitylation K660 0.644 1.285 _FNNFLK(gl)ALQEK_
XRCC5 Ubiquitylation K347 0.588 1.044 _CFSVLGFCK(gl)SSQVQR_
XRCC5 Ubiquitylation K665 0.630 0.990 _ALQEK(gl)VEIK_
XRCC5 Ubiquitylation K332 -0.032 0.491 _VDEEQMK(gl)YK_
XRCC5 Ubiquitylation K265 -0.577 0.489 _IAAYK(gl)SILQER_
XRCC5 Ubiquitylation K702 0.626 0.332 _EEASGSSVTAEEAK(gl)K_
XRCC5 Ubiquitylation K703 0.743 0.332 _EEASGSSVTAEEAKK(gl)_
XRCC5 Ubiquitylation K534 -0.146 0.207 _SQIPLSKIK(gl)_
XRCC5 Ubiquitylation K543 0.666 0.157 _TLFPLIEAK(gl)KK_
XRCC5 Ubiquitylation K544 0.165 0.157 _TLFPLIEAKK(gl)_
XRCC5 Ubiquitylation K481 -1.648 0.087 _TDTLEDLFPTTK(gl)IPNPR_
XRCC5 Ubiquitylation K532 0.343 -0.001 _SQIPLSK(gl)IK_
XRCC5 Ubiquitylation K195 -0.495 -0.075 _LGGHGPSFPLK(gl)GITEQQK_
XRCC5 Ubiquitylation K325 0.022 -0.122 _YGSDIVPFSK(gl)VDEEQMK_
XRCC5 Ubiquitylation K282 0.763 _TWTVVDAK(gl)TLKK_

Background Information for XRCC5:


Pubmed-XRCC5 »
Uniprot-XRCC5 »
Biogrid-XRCC5 »
ProteomicsDB-XRCC5 »

Tumorportal-XRCC5 »
COSMIC-XRCC5 »
GenomeRNAi-XRCC5 »
Genecards-XRCC5


Protein-protein Interactions for XRCC5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait XRCC5 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK5RAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XRCC5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SPOC_like_C_dom IPR016194 0.9
Category members Ku_C IPR005160 0.28
Category members Ku_N IPR005161 0.28
Category members Ku70/Ku80_beta-barrel_dom IPR006164 0.28
Category members VWF_A IPR002035 0


Protein complexes (CORUM database) featuring XRCC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1193 Rap1 complex Database 2.66
Category members Corum 1189 DNA double-strand break end-joining complex Database 2.16
Category members Corum 5231 53BP1-containing complex Database 1.75
Category members Corum 2766 TERF2-RAP1 complex Database 1.52
Category members Corum 5176 MGC1-DNA-PKcs-Ku complex Database 1.21
Category members Corum 5183 DNA-PK-Ku-eIF2-NF90-NF45 complex Database 0.83
Category members Corum 5179 NCOA6-DNA-PK-Ku-PARP1 complex Database 0.7
Category members Corum 1092 PCNA-KU antigen complex Database 0.68
Category members Corum 1220 TRF2-Ku complex Database 0.68
Category members Corum 322 DNA-PK-Ku complex Database 0.68
Category members Corum 355 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 356 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 357 DNA-PK-Ku antigen complex Database 0.68
Category members Corum 5182 DNA-PK-Ku complex Database 0.68
Category members Corum 95 Ku antigen-NARG1 complex Database 0.65
Category members Corum 2918 Ku antigen-YY1-alphaMyHC promoter complex Database 0.49
Category members Corum 3102 DHX9-ADAR-vigilin-DNA-PK-Ku antigen complex Database 0.44
Category members Corum 1571 Vigilin-DNA-PK-Ku antigen complex Database 0.31
Category members Corum 5235 WRN-Ku70-Ku80-PARP1 complex Database 0.31
Category members Corum 328 Ku antigen complex Database 0.28
Category members Corum 4081 Ku70/Ku86 complex Database 0.28
Category members Corum 4082 Ku70/Ku86/Werner complex Database 0.11
Category members Corum 5251 Ku-ORC complex Database 0


Categories featuring XRCC5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004003 ATP-dependent DNA helicase activity Database 4.66
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0043234 protein complex Database 2.73
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_870 PID_BARD1_PATHWAY 0 2.44
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_859 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 0 1.34
Category members GO Category GO:0042162 telomeric DNA binding Database 1.23
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members Pathway Pathway_981 REACTOME_INTEGRATION_OF_PROVIRUS 0 0.76
Category members GO Category GO:0060218 hematopoietic stem cell differentiation Database 0.74
Category members GO Category GO:0003690 double-stranded DNA binding Database 0.66
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0070419 nonhomologous end joining complex Database 0.65
Category members GO Category GO:0003691 double-stranded telomeric DNA binding Database 0.62
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members Pathway Pathway_880 PID_AR_PATHWAY 0 0.58
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members Pathway Pathway_860 KEGG_NON_HOMOLOGOUS_END_JOINING 0 0.52
Category members GO Category GO:0071398 cellular response to fatty acid Database 0.35
Category members GO Category GO:0043564 Ku70:Ku80 complex Database 0.28
Category members GO Category GO:0000783 nuclear telomere cap complex Database 0.11
Category members GO Category GO:0016817 hydrolase activity, acting on acid anhydrides Database 0.06
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0050769 positive regulation of neurogenesis Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members Pathway Pathway_967 PID_DNA_PK_PATHWAY 0 0.04
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0051575 5'-deoxyribose-5-phosphate lyase activity Database 0


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