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Query: TSG101

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TSG101 0 0.521 0.060 -0.480

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TSG101 Ubiquitylation K257 0.192 0.329 _AQAELNALK(gl)R_
TSG101 Ubiquitylation K237 -1.467 0.252 _ASLISAVSDK(gl)LR_

Background Information for TSG101:


Pubmed-TSG101 »
Uniprot-TSG101 »
Biogrid-TSG101 »
ProteomicsDB-TSG101 »

Tumorportal-TSG101 »
COSMIC-TSG101 »
GenomeRNAi-TSG101 »
Genecards-TSG101


Protein-protein Interactions for TSG101
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP55 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait PCK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PTPN23 Cat. description Hein, Mann, Cell 2015
Category members IP bait SPAST Cat. description Hein, Mann, Cell 2015
Category members IP bait TFG Cat. description Hein, Mann, Cell 2015
Category members IP bait TSG101 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS28 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VPS37D Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TSG101
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members UEV_N IPR008883 0
Category members UBQ-conjugating_enzyme/RWD IPR016135 0


Protein complexes (CORUM database) featuring TSG101
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1863 TSG101-VPS37B-VPS28 complex Database 0.04
Category members Corum 1192 ESCRT-I complex Database 0


Categories featuring TSG101
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0043130 ubiquitin binding Database 1.22
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0051301 cell division Database 1.15
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members GO Category GO:0016197 endosomal transport Database 0.43
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0048306 calcium-dependent protein binding Database 0.17
Category members GO Category GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Database 0.09
Category members GO Category GO:0005770 late endosome Database 0.09
Category members Pathway Pathway_800 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT 0 0.06
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0000813 ESCRT I complex Database 0.04
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members Pathway Pathway_833 REACTOME_MEMBRANE_BINDING_AND_TARGETTING_OF_GAG_PROTEINS 0 0
Category members GO Category GO:0001558 regulation of cell growth Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0005771 multivesicular body Database 0
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0019068 virion assembly Database 0
Category members GO Category GO:0019082 viral protein processing Database 0
Category members GO Category GO:0030216 keratinocyte differentiation Database 0
Category members GO Category GO:0031902 late endosome membrane Database 0


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