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Query: TPP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TPP1 0 4.019 -0.540 0.760 0.431 1.429 1.399

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for TPP1:


Pubmed-TPP1 »
Uniprot-TPP1 »
Biogrid-TPP1 »
ProteomicsDB-TPP1 »

Tumorportal-TPP1 »
COSMIC-TPP1 »
GenomeRNAi-TPP1 »
Genecards-TPP1


Protein-protein Interactions for TPP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCDC88A Cat. description Hein, Mann, Cell 2015
Category members IP bait MBD2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NLRP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TPP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TPP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_S8/S53_dom IPR000209 0
Category members Prot_inh_propept IPR009020 0


Protein complexes (CORUM database) featuring TPP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TPP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0030163 protein catabolic process Database 0.38
Category members GO Category GO:0008240 tripeptidyl-peptidase activity Database 0.27
Category members Pathway Pathway_148 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S 0 0.11
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0043202 lysosomal lumen Database 0.07
Category members GO Category GO:0004252 serine-type endopeptidase activity Database 0.05
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0007040 lysosome organization Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0008236 serine-type peptidase activity Database 0
Category members GO Category GO:0042277 peptide binding Database 0
Category members GO Category GO:0043171 peptide catabolic process Database 0
Category members GO Category GO:0045453 bone resorption Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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