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Query: THRAP3

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
THRAP3 3 9.100 1.430 -0.880 0.813 -0.969 0.662 0.407 0.317
THRAP3 3 9.100 1.430 -0.880 1.711 -1.395 0.117 0.304 -0.373

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
THRAP3 Phosphorylation S211 3.487 3.148 _EQTFSGGTS(ph)QDTK_
THRAP3 Phosphorylation S377 2.629 2.451 _IKEKGS(ph)FSDTGLGDGK_
THRAP3 Phosphorylation S253 0.721 1.235 _SPALKS(ph)PLQSVVVR_
THRAP3 Phosphorylation S379 0.975 1.024 _GSFS(ph)DTGLGDGK_
THRAP3 Phosphorylation S575 1.245 0.792 _MDS(ph)FDEDLARPSGLLAQER_
THRAP3 Phosphorylation S928 0.752 0.713 _WAHDKFS(ph)GEEGEIEDDESGTENR_
THRAP3 Phosphorylation S684 0.619 0.637 _RIDISPS(ph)TFRK_
THRAP3 Phosphorylation S315 0.541 _KS(ph)PVGKS(ph)PPSTGSTYGSSQK_
THRAP3 Phosphorylation S682 0.380 0.508 _IDIS(ph)PSTFR_
THRAP3 Phosphorylation S939 0.345 0.471 _FSGEEGEIEDDES(ph)GTENR_
THRAP3 Phosphorylation S243 0.422 0.427 _ASAVSELS(ph)PR_
THRAP3 Phosphorylation S248 0.461 0.278 _ERS(ph)PALKSPLQSVVVR_
THRAP3 Phosphorylation S184 0.079 0.248 _SSS(ph)KDSRPSQAAGDNQGDEAK_
THRAP3 Phosphorylation S672 0.274 0.190 _NKKS(ph)PEIHR_
THRAP3 Phosphorylation S320 -0.234 -0.545 _KSPVGKS(ph)PPSTGSTYGSSQK_
THRAP3 Phosphorylation S232 -0.501 -0.585 _ASESSKPWPDATYGTGS(ph)ASR_
THRAP3 Phosphorylation T874 -1.185 -1.519 _NREEEWDPEYT(ph)PK_
THRAP3 Phosphorylation T210 3.824 _EQTFSGGT(ph)SQDTK_
THRAP3 Phosphorylation T953 -0.085 _FSGEEGEIEDDESGTENREEKDNIQPT(ph)TE_

Background Information for THRAP3:


Pubmed-THRAP3 »
Uniprot-THRAP3 »
Biogrid-THRAP3 »
ProteomicsDB-THRAP3 »

Tumorportal-THRAP3 »
COSMIC-THRAP3 »
GenomeRNAi-THRAP3 »
Genecards-THRAP3


Protein-protein Interactions for THRAP3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCLAF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SLAIN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait THOC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APOBEC3D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C11orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHCHD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LLGL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LUC7L2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PNN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRMT8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF13B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRA2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait U2AF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in THRAP3
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring THRAP3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 535 TRAP complex Database 0.76
Category members Corum 300 PC2 complex Database 0.53
Category members Corum 66 TRAP complex Database 0.46
Category members Corum 301 SMCC complex Database 0.45
Category members Corum 547 SMCC complex Database 0.31


Categories featuring THRAP3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0030521 androgen receptor signaling pathway Database 1.25
Category members GO Category GO:0016592 mediator complex Database 0.53
Category members GO Category GO:0000381 regulation of alternative mRNA splicing, via spliceosome Database 0.5
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0051219 phosphoprotein binding Database 0.33
Category members GO Category GO:0035145 exon-exon junction complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0003712 transcription cofactor activity Database 0.21
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity Database 0.12
Category members GO Category GO:0001104 RNA polymerase II transcription cofactor activity Database 0.08
Category members GO Category GO:0000956 nuclear-transcribed mRNA catabolic process Database 0.04
Category members GO Category GO:0048026 positive regulation of mRNA splicing, via spliceosome Database 0.04
Category members GO Category GO:0046966 thyroid hormone receptor binding Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0030518 intracellular steroid hormone receptor signaling pathway Database 0
Category members GO Category GO:0042809 vitamin D receptor binding Database 0
Category members GO Category GO:0048255 mRNA stabilization Database 0


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