bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: SMARCE1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMARCE1 0 1.950 -0.270 0.280 0.251 0.796 0.284 0.349
SMARCE1 0 1.950 -0.270 0.280 0.341

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMARCE1 Ubiquitylation K271 -0.418 -0.010 _FLESTDSFNNELK(gl)R_
SMARCE1 Ubiquitylation K92 0.706 _ASNPDLK(gl)LWEIGK_

Background Information for SMARCE1:


Pubmed-SMARCE1 »
Uniprot-SMARCE1 »
Biogrid-SMARCE1 »
ProteomicsDB-SMARCE1 »

Tumorportal-SMARCE1 »
COSMIC-SMARCE1 »
GenomeRNAi-SMARCE1 »
Genecards-SMARCE1


Protein-protein Interactions for SMARCE1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL7C Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMARCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMARCE1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HMG_box_dom IPR009071 0.31
Category members GCN5L1 IPR009395 0


Protein complexes (CORUM database) featuring SMARCE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 1230 WINAC complex Database 3.79
Category members Corum 713 BRG1-SIN3A complex Database 3.51
Category members Corum 1252 EBAFa complex Database 2.5
Category members Corum 806 BRM-SIN3A-HDAC complex Database 2.48
Category members Corum 1237 BAF complex Database 2.03
Category members Corum 555 BAF complex Database 2.03
Category members Corum 564 BAF complex Database 2.03
Category members Corum 803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I Database 2.01
Category members Corum 1239 EBAFb complex Database 1.57
Category members Corum 1251 BAF complex Database 1.57
Category members Corum 238 SWI-SNF chromatin remodeling-related-BRCA1 complex Database 1.57
Category members Corum 554 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 565 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 566 BAF complex Database 1.57
Category members Corum 710 Brg1-associated complex I Database 1.57
Category members Corum 711 Brm-associated complex Database 1.57
Category members Corum 808 BRM-associated complex Database 1.57
Category members Corum 149 PBAF complex (Polybromo- and BAF containing complex) Database 1.36
Category members Corum 189 BAF complex Database 1.36
Category members Corum 3065 RNA polymerase II complex, chromatin structure modifying Database 1.26
Category members Corum 5184 SWI/SNF chromatin-remodeling complex Database 1.23
Category members Corum 1238 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 556 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 807 BRG1-associated complex Database 1.16
Category members Corum 86 NUMAC complex (nucleosomal methylation activator complex) Database 0.83
Category members Corum 5158 SMARCA2/BRM-BAF57-MECP2 complex Database 0.43


Categories featuring SMARCE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006337 nucleosome disassembly Database 3
Category members GO Category GO:0016514 SWI/SNF complex Database 2.12
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_1260 PID_ERB_GENOMIC_PATHWAY 0 1.04
Category members GO Category GO:0016922 ligand-dependent nuclear receptor binding Database 0.89
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members Disease phenotype COFFIN-SIRIS_SYNDROME COFFIN-SIRIS SYNDROME Database 0.53
Category members Disease phenotype Coffin_Siris Coffin Siris Database 0.43
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0008080 N-acetyltransferase activity Database 0.06
Category members Disease phenotype Familial_multiple_meningioma Familial multiple meningioma Database 0
Category members GO Category GO:0007399 nervous system development Database 0


.

© Copyright Svejstrup Laboratory 2015