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Query: SMARCC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMARCC2 0 4.567 -0.770 0.630
SMARCC2 0 4.567 -0.770 0.630 0.151 0.139 0.622 0.709 0.505

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMARCC2 Phosphorylation S283 0.602 0.869 _TLTDEVNS(ph)PDSDRR_
SMARCC2 Ubiquitylation K902 0.641 0.460 _KLEIK(gl)LR_
SMARCC2 Phosphorylation S302 -0.755 -0.668 _RS(ph)PSPSPTPEAK_
SMARCC2 Phosphorylation S347 -0.627 -0.862 _DMDEPS(ph)PVPNVEEVTLPK_
SMARCC2 Ubiquitylation K161 -0.199 _LKDIIK(gl)R_
SMARCC2 Ubiquitylation K455 -0.775 _ALPEFFNGKNK(gl)_
SMARCC2 Ubiquitylation K694 0.389 _VASAAAK(gl)SALEEFSK_
SMARCC2 Ubiquitylation K872 -0.712 _DIGEGNLSTAAAAALAAAAVK(gl)AK_
SMARCC2 Ubiquitylation K874 0.402 _AK(gl)HLAAVEER_

Background Information for SMARCC2:


Pubmed-SMARCC2 »
Uniprot-SMARCC2 »
Biogrid-SMARCC2 »
ProteomicsDB-SMARCC2 »

Tumorportal-SMARCC2 »
COSMIC-SMARCC2 »
GenomeRNAi-SMARCC2 »
Genecards-SMARCC2


Protein-protein Interactions for SMARCC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCL7C Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMARCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACTL6A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL7C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPF3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUP50 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RELB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMARCE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SS18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TEX13A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMARCC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Chromo_domain/shadow IPR000953 2.84
Category members Chromodomain-like IPR016197 2.29
Category members SANT/Myb IPR001005 2.18
Category members BRCT_dom IPR001357 1.59
Category members SWIRM IPR007526 1.31
Category members Myb-like_dom IPR017877 0.63
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring SMARCC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 739 SIN3-ING1b complex II Database 4.24
Category members Corum 714 BRM-SIN3A complex Database 4.02
Category members Corum 1230 WINAC complex Database 3.79
Category members Corum 713 BRG1-SIN3A complex Database 3.51
Category members Corum 1252 EBAFa complex Database 2.5
Category members Corum 806 BRM-SIN3A-HDAC complex Database 2.48
Category members Corum 1237 BAF complex Database 2.03
Category members Corum 555 BAF complex Database 2.03
Category members Corum 564 BAF complex Database 2.03
Category members Corum 803 BRG1-SIN3A-HDAC containing SWI/SNF remodeling complex I Database 2.01
Category members Corum 1239 EBAFb complex Database 1.57
Category members Corum 1251 BAF complex Database 1.57
Category members Corum 238 SWI-SNF chromatin remodeling-related-BRCA1 complex Database 1.57
Category members Corum 554 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 565 PBAF complex (Polybromo- and BAF containing complex) Database 1.57
Category members Corum 566 BAF complex Database 1.57
Category members Corum 710 Brg1-associated complex I Database 1.57
Category members Corum 711 Brm-associated complex Database 1.57
Category members Corum 808 BRM-associated complex Database 1.57
Category members Corum 5614 Emerin complex 32 Database 1.48
Category members Corum 149 PBAF complex (Polybromo- and BAF containing complex) Database 1.36
Category members Corum 189 BAF complex Database 1.36
Category members Corum 3065 RNA polymerase II complex, chromatin structure modifying Database 1.26
Category members Corum 1238 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 556 PBAF complex (Polybromo- and BAF containing complex) Database 1.16
Category members Corum 807 BRG1-associated complex Database 1.16
Category members Corum 86 NUMAC complex (nucleosomal methylation activator complex) Database 0.83
Category members Corum 1413 NCOR1 complex Database 0.65
Category members Corum 3064 RNA polymerase II complex, chromatin structure modifying Database 0.64
Category members Corum 3067 RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying Database 0.63
Category members Corum 3063 Brg1-associated complex II Database 0.62
Category members Corum 570 p300-CBP-p270-SWI/SNF complex Database 0.62
Category members Corum 2852 Brg1-based SWI/SNF chromatin remodeling complex Database 0.23
Category members Corum 2829 RSmad complex Database 0.06


Categories featuring SMARCC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members GO Category GO:0006337 nucleosome disassembly Database 3
Category members GO Category GO:0016514 SWI/SNF complex Database 2.12
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_45 PID_REG_GR_PATHWAY 0 0.31
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0006357 regulation of transcription from RNA polymerase II promoter Database 0.19
Category members GO Category GO:0007399 nervous system development Database 0


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