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Query: RRM1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RRM1 1 4.941 0.717 1.039 0.509

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RRM1 Ubiquitylation K496 0.699 1.559 _IIDINYYPVPEACLSNK(gl)R_
RRM1 Ubiquitylation K471 1.117 1.347 _LAEVTK(gl)VVVR_
RRM1 Ubiquitylation K158 0.366 0.759 _SYLLK(gl)INGK_
RRM1 Ubiquitylation K733 0.748 _QGLK(gl)TGMYYLR_
RRM1 Ubiquitylation K689 0.606 _TVWEISQK(gl)TVLK_
RRM1 Ubiquitylation K590 -0.395 0.551 _IAK(gl)YGIR_
RRM1 Ubiquitylation K587 0.487 _VLKEK(gl)IAK_
RRM1 Ubiquitylation K693 0.427 _TVLK(gl)MAAER_
RRM1 Ubiquitylation K376 0.409 0.370 _LYASYEK(gl)QGR_
RRM1 Ubiquitylation K465 -0.049 0.272 _K(gl)LAEVTK_
RRM1 Ubiquitylation K414 0.015 _K(gl)SNQQNLGTIK_
RRM1 Ubiquitylation K754 -0.746 -1.217 _TRPAANPIQFTLNK(gl)EK_
RRM1 Ubiquitylation K756 -0.746 -1.217 _TRPAANPIQFTLNK(gl)EK_

Background Information for RRM1:


Pubmed-RRM1 »
Uniprot-RRM1 »
Biogrid-RRM1 »
ProteomicsDB-RRM1 »

Tumorportal-RRM1 »
COSMIC-RRM1 »
GenomeRNAi-RRM1 »
Genecards-RRM1


Protein-protein Interactions for RRM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait RNASEH2B Cat. description Hein, Mann, Cell 2015
Category members IP bait TRIM33 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBR5 Cat. description Hein, Mann, Cell 2015
Category members IP bait KAT5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM184A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM69 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RRM1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring RRM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring RRM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members GO Category GO:0017076 purine nucleotide binding Database 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0051290 protein heterotetramerization Database 0.05
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_27 KEGG_GLUTATHIONE_METABOLISM 0 0
Category members Pathway Pathway_274 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 0 0
Category members GO Category GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Database 0
Category members GO Category GO:0006206 pyrimidine nucleobase metabolic process Database 0
Category members GO Category GO:0008584 male gonad development Database 0
Category members GO Category GO:0009263 deoxyribonucleotide biosynthetic process Database 0
Category members GO Category GO:0015949 nucleobase-containing small molecule interconversion Database 0
Category members GO Category GO:0021846 cell proliferation in forebrain Database 0
Category members GO Category GO:0042995 cell projection Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0060041 retina development in camera-type eye Database 0


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