bioLOGIC-db

bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

Query: RFC1

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
W

[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
RFC1	3	10.317	2.530	-1.230		0.635	1.060	1.028	0.826

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
RFC1	Phosphorylation	S190	2.756	2.241	_ELS(ph)QNTDESGLNDEAIAK_
RFC1	Phosphorylation	T161	2.131	1.586	_NKPLS(ph)PIKLT(ph)PTSVLDYFGTGSVQR_
RFC1	Phosphorylation	T163		1.551	_NKPLS(ph)PIKLTPT(ph)SVLDYFGTGSVQR_
RFC1	Ubiquitylation	K240		0.991	_TLAMLDEEPKTKK(gl)_
RFC1	Phosphorylation	S368	0.431	0.440	_KESVS(ph)PEDSEK_
RFC1	Phosphorylation	S156	-0.050	0.188	_NKPLS(ph)PIK_
RFC1	Ubiquitylation	K271	0.551		_VK(gl)TAQVSDERK_
RFC1	Ubiquitylation	K436	-0.227		_YGGK(gl)VTGNVSK_
RFC1	Ubiquitylation	K498	0.781		_SKYEIAVETEMK(gl)K_
RFC1	Ubiquitylation	K499	0.781		_SKYEIAVETEMK(gl)K_

Background Information for RFC1:

Pubmed-RFC1 »

Uniprot-RFC1 »

Biogrid-RFC1 »

ProteomicsDB-RFC1 »

Tumorportal-RFC1 »

COSMIC-RFC1 »

GenomeRNAi-RFC1 »

Genecards-RFC1

Protein-protein Interactions for RFC1

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait BRWD3	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait C10orf12	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait DAXX	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait EIF3I	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait EMC2	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait HNRNPU	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait IBTK	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait KCTD5	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait NOP56	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait PCNA	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait RPL35	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait RRBP1	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait FGF3	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait H2AFY2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RFC4	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RFC5	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RPL18A	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait RRP8	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait TEAD2	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015
Category members	IP bait THBS3	Cat. description	BioPlex, Huttlin, Gygi, Cell 2015

Protein Domains in RFC1

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	P-loop_NTPase	IPR027417	2.83
Category members	BRCT_dom	IPR001357	1.59
Category members	AAA+_ATPase	IPR003593	0.38
Category members	ATPase_AAA_core	IPR003959	0.14
Category members	DNA_pol3_clamp-load_cplx_C	IPR008921	0

Protein complexes (CORUM database) featuring RFC1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	Corum	433	BASC complex (BRCA1-associated genome surveillance complex)	Database	1.74
Category members	Corum	434	BASC (Ab 80) complex (BRCA1-associated genome surveillance complex)	Database	0.83
Category members	Corum	1004	RC complex during S-phase of cell cycle	Database	0.79
Category members	Corum	1005	RC complex during G2/M-phase of cell cycle	Database	0.67
Category members	Corum	1098	DNA synthesome complex (13 subunits)	Database	0.35
Category members	Corum	435	BASC (Ab 81) complex (BRCA1-associated genome surveillance complex)	Database	0.23
Category members	Corum	1099	DNA synthesome complex (17 subunits)	Database	0.22
Category members	Corum	1111	DNA synthesome complex (17 subunits)	Database	0.22
Category members	Corum	1003	RC complex (Replication competent complex)	Database	0
Category members	Corum	1107	DNA synthesome core complex	Database	0
Category members	Corum	1108	DNA synthesome complex (15 subunits)	Database	0
Category members	Corum	2203	BRD4-RFC complex	Database	0
Category members	Corum	277	RFC complex	Database	0
Category members	Corum	279	RFC complex (activator A 1 complex)	Database	0
Category members	Corum	2799	RFC complex	Database	0

Categories featuring RFC1

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	DDR Literature	pubmedid:24332808	Marechal et al., 2014 RPA-mediated recruitment		INF
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0005654	nucleoplasm	Database	INF
Category members	GO Category	GO:0006281	DNA repair	Database	INF
Category members	GO Category	GO:0005730	nucleolus	Database	13.38
Category members	GO Category	GO:0005737	cytoplasm	Database	12.81
Category members	GO Category	GO:0000278	mitotic cell cycle	Database	10.63
Category members	GO Category	GO:0006289	nucleotide-excision repair	Database	6.65
Category members	GO Category	GO:0006283	transcription-coupled nucleotide-excision repair	Database	6.58
Category members	GO Category	GO:0000723	telomere maintenance	Database	6.3
Category members	GO Category	GO:0000166	nucleotide binding	Database	5.91
Category members	GO Category	GO:0005524	ATP binding	Database	5.54
Category members	Pathway	Pathway_339	KEGG_NUCLEOTIDE_EXCISION_REPAIR	0	4.91
Category members	GO Category	GO:0006260	DNA replication	Database	3.34
Category members	GO Category	GO:0043234	protein complex	Database	2.73
Category members	GO Category	GO:0019904	protein domain specific binding	Database	1.85
Category members	GO Category	GO:0003677	DNA binding	Database	1.53
Category members	GO Category	GO:0006271	DNA strand elongation involved in DNA replication	Database	1.33
Category members	GO Category	GO:0045892	negative regulation of transcription, DNA-dependent	Database	1.15
Category members	GO Category	GO:0006351	transcription, DNA-templated	Database	1.07
Category members	Pathway	Pathway_341	KEGG_MISMATCH_REPAIR	0	1.02
Category members	GO Category	GO:0007004	telomere maintenance via telomerase	Database	0.98
Category members	Pathway	Pathway_329	KEGG_DNA_REPLICATION	0	0.95
Category members	GO Category	GO:0043085	positive regulation of catalytic activity	Database	0.78
Category members	GO Category	GO:0003690	double-stranded DNA binding	Database	0.66
Category members	GO Category	GO:0000722	telomere maintenance via recombination	Database	0.64
Category members	GO Category	GO:0017111	nucleoside-triphosphatase activity	Database	0.5
Category members	GO Category	GO:0006261	DNA-dependent DNA replication	Database	0.48
Category members	GO Category	GO:0032201	telomere maintenance via semi-conservative replication	Database	0.35
Category members	GO Category	GO:0045893	positive regulation of transcription, DNA-dependent	Database	0.28
Category members	GO Category	GO:0006297	nucleotide-excision repair, DNA gap filling	Database	0.25
Category members	GO Category	GO:0043565	sequence-specific DNA binding	Database	0.18
Category members	GO Category	GO:0008047	enzyme activator activity	Database	0.15
Category members	GO Category	GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Database	0.02
Category members	Pathway	Pathway_650	PID_FAS_PATHWAY	0	0
Category members	Pathway	Pathway_872	BIOCARTA_ALK_PATHWAY	0	0
Category members	GO Category	GO:0003689	DNA clamp loader activity	Database	0
Category members	GO Category	GO:0005663	DNA replication factor C complex	Database	0
Category members	GO Category	GO:0006355	regulation of transcription, DNA-dependent	Database	0