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Query: REST

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
REST 0 -4.973 -0.120 -0.050 -0.002 -1.235 -0.636

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
REST Phosphorylation S864 -3.456 _ESVSTEDLSPPS(ph)PPLPK_
REST Ubiquitylation K280 0.406 _VYTCGK(gl)CNYFSDR_

Background Information for REST:


Pubmed-REST »
Uniprot-REST »
Biogrid-REST »
ProteomicsDB-REST »

Tumorportal-REST »
COSMIC-REST »
GenomeRNAi-REST »
Genecards-REST


Protein-protein Interactions for REST
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait WIZ Cat. description Hein, Mann, Cell 2015


Protein Domains in REST
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_C2H2-like IPR015880 1.29
Category members Znf_C2H2 IPR007087 0.92


Protein complexes (CORUM database) featuring REST
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1232 REST-CoREST-mSIN3A complex Database 0.08


Categories featuring REST
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0070933 histone H4 deacetylation Database 0.37
Category members GO Category GO:0008134 transcription factor binding Database 0.37
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0017053 transcriptional repressor complex Database 0.28
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members GO Category GO:0043922 negative regulation by host of viral transcription Database 0.12
Category members GO Category GO:0001047 core promoter binding Database 0.11
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0060379 cardiac muscle cell myoblast differentiation Database 0.1
Category members GO Category GO:0071257 cellular response to electrical stimulus Database 0.08
Category members GO Category GO:0045665 negative regulation of neuron differentiation Database 0.04
Category members GO Category GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0001046 core promoter sequence-specific DNA binding Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010629 negative regulation of gene expression Database 0
Category members GO Category GO:0015271 outward rectifier potassium channel activity Database 0
Category members GO Category GO:0032348 negative regulation of aldosterone biosynthetic process Database 0
Category members GO Category GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Database 0
Category members GO Category GO:0045955 negative regulation of calcium ion-dependent exocytosis Database 0
Category members GO Category GO:0046676 negative regulation of insulin secretion Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050768 negative regulation of neurogenesis Database 0
Category members GO Category GO:0071385 cellular response to glucocorticoid stimulus Database 0


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