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Query: RACGAP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RACGAP1 0 3.998 0.180 0.230 -0.308 -0.006
RACGAP1 0 3.998 1.070 -0.710 -0.308 -0.006

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RACGAP1 Ubiquitylation K84 0.484 0.846 _NQVDVEIK(gl)RR_
RACGAP1 Phosphorylation S203 1.255 0.831 _S(ph)IGSAVDQGNESIVAK_
RACGAP1 Ubiquitylation K71 0.352 0.233 _SALDVK(gl)LK_
RACGAP1 Phosphorylation S590 -0.415 -0.021 _TPS(ph)SSSLSQR_
RACGAP1 Phosphorylation S591 -0.217 _TPSS(ph)SSLSQR_
RACGAP1 Ubiquitylation K199 -2.285 -0.347 _QFVDGPPGPVK(gl)K_
RACGAP1 Ubiquitylation K200 -0.365 -0.347 _QFVDGPPGPVKK(gl)_
RACGAP1 Phosphorylation T342 -1.072 -0.919 _DRCPLPCIPTLIGT(ph)PVK_
RACGAP1 Ubiquitylation K53 0.960 _TDHELGK(gl)YK_
RACGAP1 Ubiquitylation K60 1.380 _DLLMK(gl)AETER_
RACGAP1 Ubiquitylation K95 -0.492 _AEADCEK(gl)LER_
RACGAP1 Ubiquitylation K292 -0.427 _LHDFVSK(gl)TVIKPESCVPCGK_
RACGAP1 Ubiquitylation K305 -0.770 _TVIKPESCVPCGK(gl)R_
RACGAP1 Ubiquitylation K404 -0.200 _VK(gl)TVPLLSK_
RACGAP1 Ubiquitylation K490 0.528 _VAQSPHTK(gl)MDVANLAK_
RACGAP1 Phosphorylation T580 -0.839 _VSLLGPVTT(ph)PEHQLLK_
RACGAP1 Ubiquitylation K587 -0.985 _VSLLGPVTTPEHQLLK(gl)TPSSSSLSQR_
RACGAP1 Ubiquitylation K604 0.953 _STLTK(gl)NTPR_

Background Information for RACGAP1:


Pubmed-RACGAP1 »
Uniprot-RACGAP1 »
Biogrid-RACGAP1 »
ProteomicsDB-RACGAP1 »

Tumorportal-RACGAP1 »
COSMIC-RACGAP1 »
GenomeRNAi-RACGAP1 »
Genecards-RACGAP1


Protein-protein Interactions for RACGAP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD2AP Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP55 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHMP4B Cat. description Hein, Mann, Cell 2015
Category members IP bait FLOT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF23 Cat. description Hein, Mann, Cell 2015
Category members IP bait LDHD Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP1CB Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMHD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SHCBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZW10 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNFRSF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RACGAP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PE/DAG-bd IPR002219 0.63
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members Regulat_G_prot_signal_superfam IPR016137 0.05
Category members RhoGAP_dom IPR000198 0


Protein complexes (CORUM database) featuring RACGAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 929 CEN complex Database 3.25


Categories featuring RACGAP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0000281 mitotic cytokinesis Database 0.77
Category members GO Category GO:0007018 microtubule-based movement Database 0.75
Category members Pathway Pathway_669 PID_RAC1_PATHWAY 0 0.68
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0032467 positive regulation of cytokinesis Database 0.35
Category members Pathway Pathway_1314 REACTOME_KINESINS 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0007405 neuroblast proliferation Database 0.28
Category members Pathway Pathway_510 SIG_CHEMOTAXIS 0 0.28
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0043547 positive regulation of GTPase activity Database 0.21
Category members GO Category GO:0005096 GTPase activator activity Database 0.19
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0031234 extrinsic to cytoplasmic side of plasma membrane Database 0.1
Category members GO Category GO:0048487 beta-tubulin binding Database 0.1
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members Pathway Pathway_293 PID_CDC42_REG_PATHWAY 0 0.05
Category members GO Category GO:0038032 termination of G-protein coupled receptor signaling pathway Database 0.05
Category members GO Category GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding Database 0.04
Category members Pathway Pathway_1157 PID_RAC1_REG_PATHWAY 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members GO Category GO:0001669 acrosomal vesicle Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0008272 sulfate transport Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0043014 alpha-tubulin binding Database 0
Category members GO Category GO:0043015 gamma-tubulin binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051233 spindle midzone Database 0
Category members GO Category GO:0051256 spindle midzone assembly involved in mitosis Database 0
Category members GO Category GO:0051988 regulation of attachment of spindle microtubules to kinetochore Database 0


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