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Query: PARK7

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PARK7 0 2.159 -0.660 0.930

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PARK7 Ubiquitylation K41 0.222 0.590 _VTVAGLAGK(gl)DPVQCSR_
PARK7 Ubiquitylation K93 -0.291 _EILK(gl)EQENR_
PARK7 Ubiquitylation K132 0.639 _VTTHPLAKDK(gl)_

Background Information for PARK7:


Pubmed-PARK7 »
Uniprot-PARK7 »
Biogrid-PARK7 »
ProteomicsDB-PARK7 »

Tumorportal-PARK7 »
COSMIC-PARK7 »
GenomeRNAi-PARK7 »
Genecards-PARK7


Protein-protein Interactions for PARK7
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PARK7 Cat. description Hein, Mann, Cell 2015
Category members IP bait UBR5 Cat. description Hein, Mann, Cell 2015


Protein Domains in PARK7
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ThiJ/PfpI IPR002818 0
Category members Class_I_gatase-like IPR029062 0


Protein complexes (CORUM database) featuring PARK7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5830 DJ-1-SNCA complex, high molecular weight complex Database 0
Category members Corum 5837 PPD complex Database 0


Categories featuring PARK7
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0051920 peroxiredoxin activity Database 0.94
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0042743 hydrogen peroxide metabolic process Database 0.39
Category members GO Category GO:0042542 response to hydrogen peroxide Database 0.19
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0032091 negative regulation of protein binding Database 0.08
Category members Pathway Pathway_405 PID_ALPHA_SYNUCLEIN_PATHWAY 0 0.08
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members Disease phenotype Amyotrophic_lateral_sclerosis-parkinsonism-dementia_complex Amyotrophic lateral sclerosis-parkinsonism-dementia complex Database 0
Category members Disease phenotype PARKINSON_DISEASE_LATE-ONSET PARKINSON DISEASE LATE-ONSET Database 0
Category members Disease phenotype Young_adult-onset_Parkinsonism Young adult-onset Parkinsonism Database 0
Category members GO Category GO:0001963 synaptic transmission, dopaminergic Database 0
Category members GO Category GO:0004601 peroxidase activity Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0007005 mitochondrion organization Database 0
Category members GO Category GO:0007338 single fertilization Database 0
Category members GO Category GO:0008344 adult locomotory behavior Database 0
Category members GO Category GO:0034599 cellular response to oxidative stress Database 0
Category members GO Category GO:0034614 cellular response to reactive oxygen species Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043523 regulation of neuron apoptotic process Database 0
Category members GO Category GO:0050727 regulation of inflammatory response Database 0
Category members GO Category GO:0051583 dopamine uptake involved in synaptic transmission Database 0
Category members GO Category GO:0051899 membrane depolarization Database 0
Category members GO Category GO:0060081 membrane hyperpolarization Database 0
Category members GO Category GO:0060548 negative regulation of cell death Database 0
Category members GO Category GO:0060765 regulation of androgen receptor signaling pathway Database 0


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