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Query: NIPBL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NIPBL 2 8.751 -0.180 -0.270
NIPBL 2 8.751 -0.180 -0.270 1.066 1.181
NIPBL 2 8.751 -0.180 -0.270 0.759 0.809 0.590

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NIPBL Phosphorylation S553 2.102 1.878 _VDS(ph)QASITQDSDSIK_
NIPBL Phosphorylation S178 0.767 1.039 _NNTAAETEDDES(ph)DGEDRGGGTSGVR_
NIPBL Phosphorylation S280 0.496 0.816 _SPQPVCS(ph)PAGSEGTPK_
NIPBL Phosphorylation S349 0.713 0.649 _AAMYDIIS(ph)SPSKDSTK_
NIPBL Phosphorylation S306 0.689 0.413 _GSRPPLILQSQSLPCSS(ph)PR_
NIPBL Phosphorylation S350 0.226 0.375 _AAMYDIISS(ph)PSK_
NIPBL Phosphorylation S2658 0.412 0.260 _AITSLLGGGS(ph)PK_
NIPBL Phosphorylation S284 0.172 0.245 _SPQPVCSPAGS(ph)EGTPK_
NIPBL Phosphorylation S318 -0.415 -0.625 _DVPPDILLDS(ph)PERK_
NIPBL Phosphorylation T713 -0.940 -0.779 _GESRPET(ph)PKQK_
NIPBL Ubiquitylation K1628 0.366 _DAVTSK(gl)MDQGSIER_
NIPBL Phosphorylation S305 0.703 _GSRPPLILQSQSLPCS(ph)SPR_
NIPBL Phosphorylation T599 0.308 _STPENHPET(ph)PKKK_
NIPBL Phosphorylation S2672 0.868 _NNTAAETEDDES(ph)DGEDRGGGTSGSLR_

Background Information for NIPBL:


Pubmed-NIPBL »
Uniprot-NIPBL »
Biogrid-NIPBL »
ProteomicsDB-NIPBL »

Tumorportal-NIPBL »
COSMIC-NIPBL »
GenomeRNAi-NIPBL »
Genecards-NIPBL


Protein-protein Interactions for NIPBL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C1orf9;SUCO Cat. description Hein, Mann, Cell 2015
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LDHD Cat. description Hein, Mann, Cell 2015
Category members IP bait MAU2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NIPBL Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait TFG Cat. description Hein, Mann, Cell 2015
Category members IP bait ARFGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NIPBL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26


Protein complexes (CORUM database) featuring NIPBL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NIPBL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members GO Category GO:0036033 mediator complex binding Database 1.23
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0070087 chromo shadow domain binding Database 1.14
Category members Disease phenotype Cornelia_de_Lange_syndrome Cornelia de Lange syndrome Database 0.87
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members GO Category GO:0032116 SMC loading complex Database 0.32
Category members GO Category GO:0031065 positive regulation of histone deacetylation Database 0.21
Category members GO Category GO:0034088 maintenance of mitotic sister chromatid cohesion Database 0.2
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0050890 cognition Database 0.11
Category members GO Category GO:0034613 cellular protein localization Database 0.04
Category members GO Category GO:0042634 regulation of hair cycle Database 0.04
Category members GO Category GO:0048557 embryonic digestive tract morphogenesis Database 0.04
Category members GO Category GO:0007064 mitotic sister chromatid cohesion Database 0.03
Category members GO Category GO:0048703 embryonic viscerocranium morphogenesis Database 0.02
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048701 embryonic cranial skeleton morphogenesis Database 0.01
Category members GO Category GO:0001656 metanephros development Database 0
Category members GO Category GO:0003007 heart morphogenesis Database 0
Category members GO Category GO:0003151 outflow tract morphogenesis Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0007605 sensory perception of sound Database 0
Category members GO Category GO:0035115 embryonic forelimb morphogenesis Database 0
Category members GO Category GO:0035136 forelimb morphogenesis Database 0
Category members GO Category GO:0040018 positive regulation of multicellular organism growth Database 0
Category members GO Category GO:0042471 ear morphogenesis Database 0
Category members GO Category GO:0045444 fat cell differentiation Database 0
Category members GO Category GO:0045778 positive regulation of ossification Database 0
Category members GO Category GO:0045995 regulation of embryonic development Database 0
Category members GO Category GO:0048592 eye morphogenesis Database 0
Category members GO Category GO:0048638 regulation of developmental growth Database 0
Category members GO Category GO:0060325 face morphogenesis Database 0
Category members GO Category GO:0061010 gall bladder development Database 0
Category members GO Category GO:0061038 uterus morphogenesis Database 0


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