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Query: NEDD4L

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NEDD4L 0 1.800 -0.050 -0.110

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NEDD4L Ubiquitylation K639 0.649 0.864 _IMSVK(gl)RPDVLK_
NEDD4L Ubiquitylation K531 0.704 _LK(gl)FPVHMR_
NEDD4L Phosphorylation T302 0.166 0.120 _T(ph)SPQELSEELSR_
NEDD4L Phosphorylation S303 0.166 0.120 _T(ph)SPQELSEELSR_
NEDD4L Ubiquitylation K149 -0.001 0.036 _LK(gl)MAYMPK_
NEDD4L Ubiquitylation K462 -0.635 -0.011 _SLSSPTVTLSAPLEGAK(gl)DSPVRR_
NEDD4L Phosphorylation S448 0.067 -0.137 _SLS(ph)SPTVTLSAPLEGAK_
NEDD4L Phosphorylation S449 -0.460 -0.435 _SLSS(ph)PTVTLSAPLEGAK_
NEDD4L Ubiquitylation K539 -1.106 -1.175 _SK(gl)TSLNPNDLGPLPPGWEER_
NEDD4L Ubiquitylation K471 -0.787 _AVK(gl)DTLSNPQSPQPSPYNSPKPQHK_

Background Information for NEDD4L:


Pubmed-NEDD4L »
Uniprot-NEDD4L »
Biogrid-NEDD4L »
ProteomicsDB-NEDD4L »

Tumorportal-NEDD4L »
COSMIC-NEDD4L »
GenomeRNAi-NEDD4L »
Genecards-NEDD4L


Protein-protein Interactions for NEDD4L
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARRDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARRDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C12orf59 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C18orf1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM189B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ILDR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA0247 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LITAF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OCLN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRRG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM171 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM51 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM92 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFAIP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNFRSF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NEDD4L
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WW_dom IPR001202 1.15
Category members HECT IPR000569 0.04
Category members C2_dom IPR000008 0


Protein complexes (CORUM database) featuring NEDD4L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NEDD4L
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_888 KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2.22
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members Pathway Pathway_933 PID_TGFBR_PATHWAY 0 0.52
Category members GO Category GO:0017080 sodium channel regulator activity Database 0.37
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process Database 0.27
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0007179 transforming growth factor beta receptor signaling pathway Database 0.25
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Pathway Pathway_200 PID_P73PATHWAY 0 0.11
Category members GO Category GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Database 0.09
Category members GO Category GO:0006814 sodium ion transport Database 0.09
Category members GO Category GO:0007588 excretion Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0009651 response to salt stress Database 0.04
Category members GO Category GO:0010766 negative regulation of sodium ion transport Database 0.04
Category members GO Category GO:0019870 potassium channel inhibitor activity Database 0.04
Category members GO Category GO:0003254 regulation of membrane depolarization Database 0.04
Category members Pathway Pathway_644 PID_TRKR_PATHWAY 0 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway Database 0.02
Category members GO Category GO:0034765 regulation of ion transmembrane transport Database 0.02
Category members GO Category GO:0042391 regulation of membrane potential Database 0
Category members Pathway Pathway_176 KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION 0 0
Category members Disease phenotype Epileptic_encephalopathy Epileptic encephalopathy Database 0
Category members GO Category GO:0003085 negative regulation of systemic arterial blood pressure Database 0
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0006883 cellular sodium ion homeostasis Database 0
Category members GO Category GO:0010038 response to metal ion Database 0
Category members GO Category GO:0010765 positive regulation of sodium ion transport Database 0
Category members GO Category GO:0015459 potassium channel regulator activity Database 0
Category members GO Category GO:0019871 sodium channel inhibitor activity Database 0
Category members GO Category GO:0030104 water homeostasis Database 0
Category members GO Category GO:0034220 ion transmembrane transport Database 0
Category members GO Category GO:0045732 positive regulation of protein catabolic process Database 0
Category members GO Category GO:0045807 positive regulation of endocytosis Database 0
Category members GO Category GO:0060306 regulation of membrane repolarization Database 0
Category members GO Category GO:0070936 protein K48-linked ubiquitination Database 0


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