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Query: NCSTN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NCSTN 0 4.204 -1.540 2.100 0.618 0.379

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NCSTN Ubiquitylation K110 1.107 _DLMEK(gl)LK_

Background Information for NCSTN:


Pubmed-NCSTN »
Uniprot-NCSTN »
Biogrid-NCSTN »
ProteomicsDB-NCSTN »

Tumorportal-NCSTN »
COSMIC-NCSTN »
GenomeRNAi-NCSTN »
Genecards-NCSTN


Protein-protein Interactions for NCSTN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015


Protein Domains in NCSTN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_M28 IPR007484 0
Category members Nicastrin IPR008710 0


Protein complexes (CORUM database) featuring NCSTN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 142 CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) Database 0.18
Category members Corum 3128 Gamma-secretase complex (APH1B, PSEN1, PSENEN, NCSTN) Database 0.18
Category members Corum 467 Gamma-secretase complex (APH1B, PSEN2, PSENEN, NCSTN) Database 0.18
Category members Corum 2735 APH1A-PSEN2-NCSTN complex Database 0.09
Category members Corum 2734 APH1A-PSEN1-NCSTN complex Database 0.08
Category members Corum 2891 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN) Database 0.07
Category members Corum 43 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) Database 0.07
Category members Corum 45 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN variant) Database 0.07
Category members Corum 466 Gamma-secretase complex (APH1A, PSEN1, PSENEN, NCSTN) Database 0.07
Category members Corum 468 Gamma-secretase complex (APH1A, PSEN2, PSENEN, NCSTN) Database 0.07
Category members Corum 3271 Gamma-secretase-Delta1 complex Database 0


Categories featuring NCSTN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0042470 melanosome Database 5.59
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members Pathway Pathway_1074 PID_SYNDECAN_3_PATHWAY 0 0.65
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016485 protein processing Database 0.57
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members GO Category GO:0002262 myeloid cell homeostasis Database 0.3
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_739 REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 0 0.23
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0042098 T cell proliferation Database 0.21
Category members GO Category GO:0050673 epithelial cell proliferation Database 0.21
Category members Pathway Pathway_779 REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 0 0.2
Category members GO Category GO:0006509 membrane protein ectodomain proteolysis Database 0.14
Category members GO Category GO:0042987 amyloid precursor protein catabolic process Database 0.09
Category members Pathway Pathway_545 REACTOME_SIGNALING_BY_ERBB4 0 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_1159 REACTOME_REGULATED_PROTEOLYSIS_OF_P75NTR 0 0.04
Category members Pathway Pathway_557 PID_P75_NTR_PATHWAY 0 0.04
Category members Pathway Pathway_942 PID_PS1_PATHWAY 0 0.03
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_1278 REACTOME_SIGNALING_BY_NOTCH2 0 0
Category members Pathway Pathway_1279 REACTOME_SIGNALING_BY_NOTCH3 0 0
Category members Pathway Pathway_1280 REACTOME_SIGNALING_BY_NOTCH4 0 0
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_799 REACTOME_NRIF_SIGNALS_CELL_DEATH_FROM_THE_NUCLEUS 0 0
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_977 REACTOME_NUCLEAR_SIGNALING_BY_ERBB4 0 0
Category members GO Category GO:0004175 endopeptidase activity Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0007220 Notch receptor processing Database 0
Category members GO Category GO:0031293 membrane protein intracellular domain proteolysis Database 0
Category members GO Category GO:0050435 beta-amyloid metabolic process Database 0


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