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Query: LDLR

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LDLR 0 -0.328 0.610 -0.680 -0.328

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for LDLR:


Pubmed-LDLR »
Uniprot-LDLR »
Biogrid-LDLR »
ProteomicsDB-LDLR »

Tumorportal-LDLR »
COSMIC-LDLR »
GenomeRNAi-LDLR »
Genecards-LDLR


Protein-protein Interactions for LDLR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait OXNAD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait B3GNT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C6orf72 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EGFL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRPAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MGAT4C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TYW3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UST Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WNT7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFP41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF408 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LDLR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members LDLR_classB_rpt IPR000033 0
Category members LDrepeatLR_classA_rpt IPR002172 0
Category members Growth_fac_rcpt_N_dom IPR009030 0


Protein complexes (CORUM database) featuring LDLR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LDLR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0030229 very-low-density lipoprotein particle receptor activity Database 0.33
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0007603 phototransduction, visible light Database 0.25
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0001523 retinoid metabolic process Database 0.1
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0034383 low-density lipoprotein particle clearance Database 0.07
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_491 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 0 0
Category members Pathway Pathway_492 REACTOME_LIPOPROTEIN_METABOLISM 0 0
Category members Disease phenotype Homozygous_familial_hypercholesterolemia Homozygous familial hypercholesterolemia Database 0
Category members Disease phenotype HYPERCHOLESTEROLEMIA_FAMILIAL HYPERCHOLESTEROLEMIA FAMILIAL Database 0
Category members GO Category GO:0001948 glycoprotein binding Database 0
Category members GO Category GO:0005041 low-density lipoprotein receptor activity Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006898 receptor-mediated endocytosis Database 0
Category members GO Category GO:0010008 endosome membrane Database 0
Category members GO Category GO:0010867 positive regulation of triglyceride biosynthetic process Database 0
Category members GO Category GO:0010899 regulation of phosphatidylcholine catabolic process Database 0
Category members GO Category GO:0015914 phospholipid transport Database 0
Category members GO Category GO:0030169 low-density lipoprotein particle binding Database 0
Category members GO Category GO:0030299 intestinal cholesterol absorption Database 0
Category members GO Category GO:0030301 cholesterol transport Database 0
Category members GO Category GO:0030669 clathrin-coated endocytic vesicle membrane Database 0
Category members GO Category GO:0034362 low-density lipoprotein particle Database 0
Category members GO Category GO:0042157 lipoprotein metabolic process Database 0
Category members GO Category GO:0042159 lipoprotein catabolic process Database 0
Category members GO Category GO:0042632 cholesterol homeostasis Database 0
Category members GO Category GO:0070508 cholesterol import Database 0


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