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Query: ITGA6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITGA6 0 1.845 -0.530 0.420 -0.133 -0.561 -0.048

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITGA6 Ubiquitylation K1117 1.453 _YIDNLEKK(gl)_
ITGA6 Ubiquitylation K1116 0.715 _YIDNLEK(gl)K_

Background Information for ITGA6:


Pubmed-ITGA6 »
Uniprot-ITGA6 »
Biogrid-ITGA6 »
ProteomicsDB-ITGA6 »

Tumorportal-ITGA6 »
COSMIC-ITGA6 »
GenomeRNAi-ITGA6 »
Genecards-ITGA6


Protein-protein Interactions for ITGA6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait B4GALT4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTNL8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CANT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GML Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-DRB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLA-E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDH20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHB16 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHGA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PICK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PON2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTCH1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMED6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMPRSS11B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSPAN11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITGA6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FG-GAP IPR013517 0.3
Category members Int_alpha_beta-p IPR013519 0.1
Category members Integrin_alpha IPR000413 0.03
Category members Integrin_alpha-2 IPR013649 0.03
Category members Integrin_alpha_C_CS IPR018184 0


Protein complexes (CORUM database) featuring ITGA6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2411 ITGA6-ITGB1-CD151 complex Database 0.29
Category members Corum 2413 ITGA6-ITGB1 complex Database 0.09
Category members Corum 2318 ITGA6-ITGB4-Laminin10/12 complex Database 0
Category members Corum 2319 ITGA6-ITGB4-Laminin10/12 complex Database 0
Category members Corum 2320 ITGA6-ITGB4-CD151 complex Database 0
Category members Corum 2321 ITGA6-ITGB4-FYN complex Database 0
Category members Corum 2322 ITGA6-ITGB4-LAMA5 complex Database 0
Category members Corum 2323 ITGA6-ITGB4 complex Database 0
Category members Corum 2437 ITGA6-ITGB1-CYR61 complex Database 0
Category members Corum 2770 ITGA6-ITGB4-CD9 complex Database 0
Category members Corum 3096 ITGA6-ITGB4-SHC1-GRB2 complex Database 0


Categories featuring ITGA6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members GO Category GO:0005913 cell-cell adherens junction Database 1.05
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members GO Category GO:0042327 positive regulation of phosphorylation Database 0.52
Category members GO Category GO:0032403 protein complex binding Database 0.49
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_449 KEGG_HEMATOPOIETIC_CELL_LINEAGE 0 0.31
Category members GO Category GO:0034329 cell junction assembly Database 0.29
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0043065 positive regulation of apoptotic process Database 0.26
Category members Pathway Pathway_142 PID_MYC_REPRESS_PATHWAY 0 0.21
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0030056 hemidesmosome Database 0.1
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_626 PID_A6B1_A6B4_INTEGRIN_PATHWAY 0 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members GO Category GO:0030175 filopodium Database 0.05
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0008305 integrin complex Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_1286 PID_INTEGRIN_CS_PATHWAY 0 0
Category members Pathway Pathway_1290 PID_INTEGRIN4_PATHWAY 0 0
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_283 KEGG_SMALL_CELL_LUNG_CANCER 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Disease phenotype EPIDERMOLYSIS_BULLOSA_JUNCTIONALIS_WITH_PYLORIC_ATRESIA EPIDERMOLYSIS BULLOSA JUNCTIONALIS WITH PYLORIC ATRESIA Database 0
Category members Disease phenotype Junctional_epidermolysis_bullosa_-_pyloric_atresia Junctional epidermolysis bullosa - pyloric atresia Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0007044 cell-substrate junction assembly Database 0
Category members GO Category GO:0007160 cell-matrix adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0009925 basal plasma membrane Database 0
Category members GO Category GO:0010811 positive regulation of cell-substrate adhesion Database 0
Category members GO Category GO:0016337 cell-cell adhesion Database 0
Category members GO Category GO:0022409 positive regulation of cell-cell adhesion Database 0
Category members GO Category GO:0031581 hemidesmosome assembly Database 0
Category members GO Category GO:0031668 cellular response to extracellular stimulus Database 0
Category members GO Category GO:0033627 cell adhesion mediated by integrin Database 0
Category members GO Category GO:0042475 odontogenesis of dentin-containing tooth Database 0
Category members GO Category GO:0043236 laminin binding Database 0
Category members GO Category GO:0045178 basal part of cell Database 0
Category members GO Category GO:0046847 filopodium assembly Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050873 brown fat cell differentiation Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


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