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Query: ITGA5

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ITGA5 0 1.742 0.320 -0.520 0.858 0.617

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ITGA5 Phosphorylation S127 0.200 0.067 _LLESSLSS(ph)SEGEEPVEYK_
ITGA5 Phosphorylation S128 -0.087 _LLESSLSSS(ph)EGEEPVEYK_

Background Information for ITGA5:


Pubmed-ITGA5 »
Uniprot-ITGA5 »
Biogrid-ITGA5 »
ProteomicsDB-ITGA5 »

Tumorportal-ITGA5 »
COSMIC-ITGA5 »
GenomeRNAi-ITGA5 »
Genecards-ITGA5


Protein-protein Interactions for ITGA5
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ITGA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADAM32 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BTNL3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ITGA5
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members FG-GAP IPR013517 0.3
Category members Int_alpha_beta-p IPR013519 0.1
Category members Integrin_alpha IPR000413 0.03
Category members Integrin_alpha-2 IPR013649 0.03


Protein complexes (CORUM database) featuring ITGA5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2853 ITGA5-ITGB1-CAL4A3 complex Database 0.29
Category members Corum 3112 ITGA5-ITGB1-SPP1 complex Database 0.11
Category members Corum 2385 ITGA5-ITGB4 complex Database 0.09
Category members Corum 2383 ITGA5-ITGB1-FN1-TGM2 complex Database 0
Category members Corum 2384 ITGA5-ITGB1-ADAM15 complex Database 0
Category members Corum 2850 ITGA5-ITGB1-FN-1-NOV complex Database 0


Categories featuring ITGA5
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0019048 modulation by virus of host morphology or physiology Database 7.81
Category members Pathway Pathway_541 PID_FAK_PATHWAY 0 1.88
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0005911 cell-cell junction Database 1.4
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_595 KEGG_FOCAL_ADHESION 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_295 PID_ARF6_TRAFFICKING_PATHWAY 0 0.9
Category members GO Category GO:0005925 focal adhesion Database 0.68
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0001726 ruffle Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_449 KEGG_HEMATOPOIETIC_CELL_LINEAGE 0 0.31
Category members Pathway Pathway_1093 PID_SYNDECAN_4_PATHWAY 0 0.28
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members Pathway Pathway_710 PID_UPA_UPAR_PATHWAY 0 0.2
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0005178 integrin binding Database 0.09
Category members Pathway Pathway_580 KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0 0.08
Category members Pathway Pathway_1022 PID_SYNDECAN_2_PATHWAY 0 0.08
Category members GO Category GO:0045202 synapse Database 0.06
Category members Pathway Pathway_600 REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 0 0.05
Category members GO Category GO:0007157 heterophilic cell-cell adhesion Database 0.04
Category members Pathway Pathway_434 PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 0 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members GO Category GO:0008305 integrin complex Database 0.03
Category members Pathway Pathway_1007 KEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC 0 0.03
Category members GO Category GO:0009897 external side of plasma membrane Database 0
Category members Pathway Pathway_1008 KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 0 0
Category members Pathway Pathway_1027 PID_INTEGRIN1_PATHWAY 0 0
Category members Pathway Pathway_1286 PID_INTEGRIN_CS_PATHWAY 0 0
Category members Pathway Pathway_262 KEGG_DILATED_CARDIOMYOPATHY 0 0
Category members Pathway Pathway_539 PID_LYMPH_ANGIOGENESIS_PATHWAY 0 0
Category members Pathway Pathway_922 KEGG_ECM_RECEPTOR_INTERACTION 0 0
Category members Pathway Pathway_930 REACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0005154 epidermal growth factor receptor binding Database 0
Category members GO Category GO:0005161 platelet-derived growth factor receptor binding Database 0
Category members GO Category GO:0007044 cell-substrate junction assembly Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007159 leukocyte cell-cell adhesion Database 0
Category members GO Category GO:0007229 integrin-mediated signaling pathway Database 0
Category members GO Category GO:0007613 memory Database 0
Category members GO Category GO:0010811 positive regulation of cell-substrate adhesion Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway Database 0
Category members GO Category GO:0033631 cell-cell adhesion mediated by integrin Database 0
Category members GO Category GO:0035313 wound healing, spreading of epidermal cells Database 0
Category members GO Category GO:0043184 vascular endothelial growth factor receptor 2 binding Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0050839 cell adhesion molecule binding Database 0


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