bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: HSP90AB1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HSP90AB1 1 5.648 1.280 -1.050
HSP90AB1 1 5.648 1.280 -1.050 0.283 0.786 -1.175 0.317 0.463

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HSP90AB1 Ubiquitylation K559 0.847 1.549 _AK(gl)FENLCK_
HSP90AB1 Ubiquitylation K491 0.982 1.512 _SIYYITGESK(gl)EQVANSAFVER_
HSP90AB1 Ubiquitylation K531 0.745 1.350 _EFDGK(gl)SLVSVTK_
HSP90AB1 Ubiquitylation K623 0.520 1.081 _DNSTMGYM(ox)MAK(gl)K_
HSP90AB1 Ubiquitylation K435 0.847 0.933 _FYEAFSK(gl)NLK_
HSP90AB1 Phosphorylation S226 0.404 0.704 _EKEIS(ph)DDEAEEEK_
HSP90AB1 Phosphorylation S255 0.525 0.628 _IEDVGS(ph)DEEDDSGKDKK_
HSP90AB1 Phosphorylation S261 0.520 0.624 _IEDVGSDEEDDS(ph)GKDK_
HSP90AB1 Ubiquitylation K574 0.241 0.550 _EILDKK(gl)VEK_
HSP90AB1 Ubiquitylation K69 0.661 0.380 _LDSGK(gl)ELK_
HSP90AB1 Ubiquitylation K573 0.243 0.360 _EILDK(gl)KVEK_
HSP90AB1 Ubiquitylation K438 1.021 -0.058 _NLK(gl)LGIHEDSTNR_
HSP90AB1 Ubiquitylation K346 -0.224 -0.065 _RAPFDLFEK(gl)K_
HSP90AB1 Ubiquitylation K64 0.829 -0.090 _YESLTDPSK(gl)LDSGKELK_
HSP90AB1 Ubiquitylation K72 -1.242 -0.130 _ELK(gl)IDIIPNPQER_
HSP90AB1 Ubiquitylation K347 0.026 -0.302 _RAPFDLFEKK(gl)_
HSP90AB1 Ubiquitylation K347 0.110 _RAPFDLFENK(gl)K_
HSP90AB1 Ubiquitylation K348 -0.096 _RAPFDLFENKK(gl)_
HSP90AB1 Ubiquitylation K428 0.308 _K(gl)FYEAFSK_
HSP90AB1 Ubiquitylation K481 0.811 _MKETQK(gl)SIYYITGESK_
HSP90AB1 Ubiquitylation K565 -0.066 _FENLCK(gl)LMK_

Background Information for HSP90AB1:


Pubmed-HSP90AB1 »
Uniprot-HSP90AB1 »
Biogrid-HSP90AB1 »
ProteomicsDB-HSP90AB1 »

Tumorportal-HSP90AB1 »
COSMIC-HSP90AB1 »
GenomeRNAi-HSP90AB1 »
Genecards-HSP90AB1


Protein-protein Interactions for HSP90AB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC37 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHORDC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DNAJC7 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNA Cat. description Hein, Mann, Cell 2015
Category members IP bait GET4 Cat. description Hein, Mann, Cell 2015
Category members IP bait HSP90AA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IKBKG Cat. description Hein, Mann, Cell 2015
Category members IP bait IQGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait LRR1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPRE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYO19 Cat. description Hein, Mann, Cell 2015
Category members IP bait PANK4 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP5C Cat. description Hein, Mann, Cell 2015
Category members IP bait SLC33A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA3C;TUBA3E Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait AKT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AURKC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK11A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK13 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FKBP4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GBP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MYLK4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDIK1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSKH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMYD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STK11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STK35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HSP90AB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Hsp90_fam IPR001404 1.09
Category members Hsp90_N IPR020575 1.09
Category members HATPase_C IPR003594 1.07
Category members Ribosomal_S5_D2-typ_fold IPR020568 1.06


Protein complexes (CORUM database) featuring HSP90AB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5266 TNF-alpha/NF-kappa B signaling complex 6 Database 3.74
Category members Corum 5199 Kinase maturation complex 1 Database 3.38
Category members Corum 2721 HCF-1 complex Database 2.08
Category members Corum 5268 TNF-alpha/NF-kappa B signaling complex 7 Database 1.75
Category members Corum 5269 TNF-alpha/NF-kappa B signaling complex 8 Database 1.36
Category members Corum 5234 IKBKB-CDC37-KIAA1967-HSP90AB1-HSP90AA1 complex Database 0.57
Category members Corum 725 P2X7 receptor signalling complex Database 0.53
Category members Corum 2112 CDC37-HSP90AA1-HSP90AB1-MAP3K11 complex Database 0.36
Category members Corum 5285 TNF-alpha/NF-kappa B signaling complex 9 Database 0.21
Category members Corum 5212 Kinase maturation complex 2 Database 0.18
Category members Corum 5286 TNF-alpha/NF-kappa B signaling complex 10 Database 0.18
Category members Corum 5849 HSP90-CDC37-LRRK2 complex Database 0.08
Category members Corum 3032 RNA-induced silencing complex, RISC Database 0
Category members Corum 4158 HSP90-FKBP38-CAM-Ca(2+) complex Database 0
Category members Corum 5980 LRRK2-CHIP-HSP90 complex Database 0


Categories featuring HSP90AB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0051082 unfolded protein binding Database 3.74
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_1147 REACTOME_SEMA3A_PAK_DEPENDENT_AXON_REPULSION 0 1.89
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0008180 COP9 signalosome Database 1.47
Category members GO Category GO:0032564 dATP binding Database 1.31
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0017098 sulfonylurea receptor binding Database 0.65
Category members GO Category GO:0006986 response to unfolded protein Database 0.62
Category members Pathway Pathway_220 KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION 0 0.6
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members GO Category GO:0002135 CTP binding Database 0.37
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis Database 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0030235 nitric-oxide synthase regulator activity Database 0.28
Category members GO Category GO:0030911 TPR domain binding Database 0.27
Category members Pathway Pathway_1053 KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0 0.25
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_1204 REACTOME_THE_NLRP3_INFLAMMASOME 0 0.2
Category members GO Category GO:0071353 cellular response to interleukin-4 Database 0.19
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0016234 inclusion body Database 0.14
Category members GO Category GO:0002134 UTP binding Database 0.14
Category members Pathway Pathway_177 KEGG_PROSTATE_CANCER 0 0.13
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0003725 double-stranded RNA binding Database 0.1
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0060334 regulation of interferon-gamma-mediated signaling pathway Database 0.07
Category members GO Category GO:0045429 positive regulation of nitric oxide biosynthetic process Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0009651 response to salt stress Database 0.04
Category members GO Category GO:0033160 positive regulation of protein import into nucleus, translocation Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0044325 ion channel binding Database 0.03
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members GO Category GO:0001890 placenta development Database 0
Category members GO Category GO:0006950 response to stress Database 0
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0031526 brush border membrane Database 0
Category members GO Category GO:0032092 positive regulation of protein binding Database 0
Category members GO Category GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process Database 0
Category members GO Category GO:0045793 positive regulation of cell size Database 0
Category members GO Category GO:0060338 regulation of type I interferon-mediated signaling pathway Database 0
Category members GO Category GO:0071407 cellular response to organic cyclic compound Database 0


.

© Copyright Svejstrup Laboratory 2015