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Query: HGS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
HGS 0 2.532 0.020 0.300 -0.211 0.737 0.264

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
HGS Ubiquitylation K520 0.211 1.230 _QK(gl)KQEYLEVQR_
HGS Ubiquitylation K521 -1.344 1.230 _K(gl)QEYLEVQR_
HGS Ubiquitylation K207 -0.193 0.798 _FGIEK(gl)EVR_
HGS Ubiquitylation K192 0.015 0.751 _ACGQIFCGK(gl)CSSK_
HGS Ubiquitylation K202 -0.163 0.558 _YSTIPK(gl)FGIEK_
HGS Ubiquitylation K551 -0.260 0.554 _LEQQK(gl)QTVQM(ox)R_
HGS Ubiquitylation K126 0.088 0.464 _YK(gl)VVQDTYQIMK_
HGS Ubiquitylation K283 -0.826 -0.270 _QK(gl)STYTSYPK_
HGS Ubiquitylation K337 0.097 _NYWEK(gl)KQEEAR_
HGS Ubiquitylation K473 -0.154 _LYYEGLQDK(gl)LAQIR_
HGS Ubiquitylation K513 -0.289 _QIQLAQK(gl)LEIMR_

Background Information for HGS:


Pubmed-HGS »
Uniprot-HGS »
Biogrid-HGS »
ProteomicsDB-HGS »

Tumorportal-HGS »
COSMIC-HGS »
GenomeRNAi-HGS »
Genecards-HGS


Protein-protein Interactions for HGS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait HSPBP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAM Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in HGS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_FYVE_PHD IPR011011 1.23
Category members ENTH_VHS IPR008942 0.96
Category members Ubiquitin-int_motif IPR003903 0.49
Category members Znf_FYVE IPR000306 0
Category members VHS IPR002014 0
Category members Znf_FYVE-rel IPR017455 0
Category members VHS_subgr IPR018205 0


Protein complexes (CORUM database) featuring HGS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 706 SNARE complex (HGS, SNAP25, STX13) Database 0.05
Category members Corum 3677 RIN1-STAM2-HRS complex Database 0


Categories featuring HGS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_645 PID_CXCR4_PATHWAY 0 1.42
Category members GO Category GO:0005769 early endosome Database 1.26
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members GO Category GO:0042176 regulation of protein catabolic process Database 0.91
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0008333 endosome to lysosome transport Database 0.49
Category members GO Category GO:0043231 intracellular membrane-bounded organelle Database 0.43
Category members GO Category GO:0016197 endosomal transport Database 0.43
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0008285 negative regulation of cell proliferation Database 0.28
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members Pathway Pathway_294 PID_AJDISS_2PATHWAY 0 0.18
Category members Pathway Pathway_437 PID_VEGFR1_2_PATHWAY 0 0.13
Category members GO Category GO:0030141 secretory granule Database 0.11
Category members Pathway Pathway_800 REACTOME_ENDOSOMAL_SORTING_COMPLEX_REQUIRED_FOR_TRANSPORT_ESCRT 0 0.06
Category members Pathway Pathway_538 PID_ERBB1_INTERNALIZATION_PATHWAY 0 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0009966 regulation of signal transduction Database 0
Category members GO Category GO:0032585 multivesicular body membrane Database 0
Category members GO Category GO:0046426 negative regulation of JAK-STAT cascade Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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