bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: GNA11

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
GNA11 1 3.462 2.030 -1.240 0.953 0.764 0.108

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
GNA11 Ubiquitylation K27 0.292 1.135 _RINAEIEK(gl)QLR_
GNA11 Ubiquitylation K102 0.502 0.512 _ILYK(gl)YEQNK_
GNA11 Ubiquitylation K16 0.347 _(ac)TLESMMACCLSDEVK(gl)ESKR_

Background Information for GNA11:


Pubmed-GNA11 »
Uniprot-GNA11 »
Biogrid-GNA11 »
ProteomicsDB-GNA11 »

Tumorportal-GNA11 »
COSMIC-GNA11 »
GenomeRNAi-GNA11 »
Genecards-GNA11


Protein-protein Interactions for GNA11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CORO1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait DUSP22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNG3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GNG4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in GNA11
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members GproteinA_insert IPR011025 0.18
Category members Gprotein_alpha_su IPR001019 0.02
Category members Gprotein_alpha_Q IPR000654 0
Category members Fungi_Gprotein_alpha IPR002975 0


Protein complexes (CORUM database) featuring GNA11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 557 TRP1-G alpha-11-IP3R3-CAV1 signaling complex Database 0.41


Categories featuring GNA11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_237 PID_LYSOPHOSPHOLIPID_PATHWAY 0 1.09
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members Human mutations pubmedid:24460190 The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia (Bastian, 2014). Research article 0.88
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members Pathway Pathway_736 PID_S1P_META_PATHWAY 0 0.73
Category members Pathway Pathway_1078 PID_S1P_S1P2_PATHWAY 0 0.62
Category members Pathway Pathway_992 PID_ARF6_PATHWAY 0 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members Pathway Pathway_286 KEGG_LONG_TERM_DEPRESSION 0 0.31
Category members Pathway Pathway_987 PID_S1P_S1P3_PATHWAY 0 0.28
Category members Pathway Pathway_433 PID_ER_NONGENOMIC_PATHWAY 0 0.23
Category members Pathway Pathway_428 PID_THROMBIN_PAR1_PATHWAY 0 0.18
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0048066 developmental pigmentation Database 0.15
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members Pathway Pathway_233 KEGG_CALCIUM_SIGNALING_PATHWAY 0 0.13
Category members Pathway Pathway_681 REACTOME_REGULATION_OF_INSULIN_SECRETION_BY_ACETYLCHOLINE 0 0.13
Category members Pathway Pathway_56 REACTOME_PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION 0 0.11
Category members Pathway Pathway_213 KEGG_GAP_JUNCTION 0 0.11
Category members GO Category GO:0031234 extrinsic to cytoplasmic side of plasma membrane Database 0.1
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members GO Category GO:0001664 G-protein coupled receptor binding Database 0.09
Category members Pathway Pathway_513 ST_ADRENERGIC 0 0.08
Category members GO Category GO:0019001 guanyl nucleotide binding Database 0.07
Category members Pathway Pathway_721 REACTOME_SIGNAL_AMPLIFICATION 0 0.06
Category members GO Category GO:0001508 regulation of action potential Database 0.05
Category members Pathway Pathway_486 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 0 0.04
Category members GO Category GO:0031683 G-protein beta/gamma-subunit complex binding Database 0.02
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_1103 REACTOME_THROMBOXANE_SIGNALLING_THROUGH_TP_RECEPTOR 0 0
Category members Pathway Pathway_234 PID_ENDOTHELIN_PATHWAY 0 0
Category members Pathway Pathway_257 KEGG_GNRH_SIGNALING_PATHWAY 0 0
Category members Pathway Pathway_430 PID_TXA2PATHWAY 0 0
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_684 PID_THROMBIN_PAR4_PATHWAY 0 0
Category members Pathway Pathway_704 BIOCARTA_BIOPEPTIDES_PATHWAY 0 0
Category members Pathway Pathway_722 REACTOME_ADP_SIGNALLING_THROUGH_P2RY1 0 0
Category members Pathway Pathway_994 REACTOME_THROMBIN_SIGNALLING_THROUGH_PROTEINASE_ACTIVATED_RECEPTORS_PARS 0 0
Category members Disease phenotype Autosomal_dominant_hypocalcemia Autosomal dominant hypocalcemia Database 0
Category members GO Category GO:0001501 skeletal system development Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0005834 heterotrimeric G-protein complex Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0045634 regulation of melanocyte differentiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0060158 phospholipase C-activating dopamine receptor signaling pathway Database 0


.

© Copyright Svejstrup Laboratory 2015