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Query: F2RL1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
F2RL1 0 5.354 -1.330 2.490

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
F2RL1 Phosphorylation S384 0.573 1.068 _KSS(ph)SYSSSSTTVK_
F2RL1 Ubiquitylation K394 0.350 0.873 _KSSSYSSSSTTVK(gl)TSY_
F2RL1 Ubiquitylation K368 0.159 0.737 _TVK(gl)QMQVSLTSK_
F2RL1 Ubiquitylation K377 -0.040 -0.268 _QMQVSLTSK(gl)K_
F2RL1 Ubiquitylation K378 0.066 -0.268 _QMQVSLTSKK(gl)_

Background Information for F2RL1:


Pubmed-F2RL1 »
Uniprot-F2RL1 »
Biogrid-F2RL1 »
ProteomicsDB-F2RL1 »

Tumorportal-F2RL1 »
COSMIC-F2RL1 »
GenomeRNAi-F2RL1 »
Genecards-F2RL1


Protein-protein Interactions for F2RL1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait F2RL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in F2RL1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members GPCR_Rhodpsn IPR000276 2.56
Category members GPCR_Rhodpsn_7TM IPR017452 2.32
Category members Protea_act_rcpt IPR003912 0
Category members 7TM_GPCR_serpentine_rcpt_Srw IPR019427 0


Protein complexes (CORUM database) featuring F2RL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring F2RL1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_1105 REACTOME_GPCR_LIGAND_BINDING 0 2.35
Category members GO Category GO:0004930 G-protein coupled receptor activity Database 2.1
Category members Pathway Pathway_1184 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 0 1.89
Category members Pathway Pathway_1182 REACTOME_CLASS_A1_RHODOPSIN_LIKE_RECEPTORS 0 1.69
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members Pathway Pathway_243 REACTOME_GPCR_DOWNSTREAM_SIGNALING 0 1.27
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_256 REACTOME_SIGNALING_BY_GPCR 0 0.83
Category members GO Category GO:0070374 positive regulation of ERK1 and ERK2 cascade Database 0.65
Category members Pathway Pathway_1186 REACTOME_PEPTIDE_LIGAND_BINDING_RECEPTORS 0 0.54
Category members GO Category GO:0006954 inflammatory response Database 0.49
Category members GO Category GO:0031143 pseudopodium Database 0.46
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0060100 positive regulation of phagocytosis, engulfment Database 0.39
Category members GO Category GO:0030193 regulation of blood coagulation Database 0.29
Category members GO Category GO:0032930 positive regulation of superoxide anion generation Database 0.27
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0046328 regulation of JNK cascade Database 0.22
Category members GO Category GO:0030836 positive regulation of actin filament depolymerization Database 0.18
Category members GO Category GO:0031274 positive regulation of pseudopodium assembly Database 0.18
Category members GO Category GO:0015057 thrombin receptor activity Database 0.17
Category members GO Category GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0061028 establishment of endothelial barrier Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0002286 T cell activation involved in immune response Database 0.04
Category members GO Category GO:0031681 G-protein beta-subunit binding Database 0.04
Category members GO Category GO:0050900 leukocyte migration Database 0.04
Category members Pathway Pathway_486 REACTOME_G_ALPHA_Q_SIGNALLING_EVENTS 0 0.04
Category members GO Category GO:0034140 negative regulation of toll-like receptor 3 signaling pathway Database 0.04
Category members Pathway Pathway_487 REACTOME_GASTRIN_CREB_SIGNALLING_PATHWAY_VIA_PKC_AND_MAPK 0 0
Category members Pathway Pathway_725 ST_GA12_PATHWAY 0 0
Category members GO Category GO:0001965 G-protein alpha-subunit binding Database 0
Category members GO Category GO:0002690 positive regulation of leukocyte chemotaxis Database 0
Category members GO Category GO:0002741 positive regulation of cytokine secretion involved in immune response Database 0
Category members GO Category GO:0003104 positive regulation of glomerular filtration Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0005102 receptor binding Database 0
Category members GO Category GO:0007204 positive regulation of cytosolic calcium ion concentration Database 0
Category members GO Category GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway Database 0
Category members GO Category GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0030335 positive regulation of cell migration Database 0
Category members GO Category GO:0034137 positive regulation of toll-like receptor 2 signaling pathway Database 0
Category members GO Category GO:0034141 positive regulation of toll-like receptor 3 signaling pathway Database 0
Category members GO Category GO:0034145 positive regulation of toll-like receptor 4 signaling pathway Database 0
Category members GO Category GO:0035025 positive regulation of Rho protein signal transduction Database 0
Category members GO Category GO:0042119 neutrophil activation Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0045909 positive regulation of vasodilation Database 0
Category members GO Category GO:0046329 negative regulation of JNK cascade Database 0
Category members GO Category GO:0046330 positive regulation of JNK cascade Database 0
Category members GO Category GO:0050702 interleukin-1 beta secretion Database 0
Category members GO Category GO:0050921 positive regulation of chemotaxis Database 0
Category members GO Category GO:0050927 positive regulation of positive chemotaxis Database 0


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