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Query: BHLHE40

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
BHLHE40 0 -2.643 -0.330 0.040

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
BHLHE40 Ubiquitylation K159 -0.521 _EVLQYLAK(gl)HENTR_
BHLHE40 Ubiquitylation K262 -1.135 _SEQPCFK(gl)SDHGR_
BHLHE40 Phosphorylation S383 -2.162 _LPS(ph)PLPAHPSVDSSVLLQALKPIPPLNLETKD_

Background Information for BHLHE40:


Pubmed-BHLHE40 »
Uniprot-BHLHE40 »
Biogrid-BHLHE40 »
ProteomicsDB-BHLHE40 »

Tumorportal-BHLHE40 »
COSMIC-BHLHE40 »
GenomeRNAi-BHLHE40 »
Genecards-BHLHE40


Protein-protein Interactions for BHLHE40
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BTRC Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in BHLHE40
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members bHLH_dom IPR011598 0.32
Category members Orange_subgr IPR018352 0.31
Category members Orange IPR003650 0.04


Protein complexes (CORUM database) featuring BHLHE40
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring BHLHE40
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_1275 KEGG_CIRCADIAN_RHYTHM_MAMMAL 0 0.74
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0032922 circadian regulation of gene expression Database 0.21
Category members GO Category GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity Database 0.18
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0009416 response to light stimulus Database 0.06
Category members GO Category GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_1249 PID_CIRCADIAN_PATHWAY 0 0
Category members GO Category GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity Database 0
Category members GO Category GO:0001191 RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription Database 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0043153 entrainment of circadian clock by photoperiod Database 0
Category members GO Category GO:0043425 bHLH transcription factor binding Database 0
Category members GO Category GO:0043426 MRF binding Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0
Category members GO Category GO:0070888 E-box binding Database 0


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