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Query: ATP7A

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATP7A 0 0.399 -0.210 0.370

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATP7A Ubiquitylation K333 0.029 _K(gl)AIEAVSPGLYR_

Background Information for ATP7A:


Pubmed-ATP7A »
Uniprot-ATP7A »
Biogrid-ATP7A »
ProteomicsDB-ATP7A »

Tumorportal-ATP7A »
COSMIC-ATP7A »
GenomeRNAi-ATP7A »
Genecards-ATP7A


Protein-protein Interactions for ATP7A
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC13 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP7A Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APBB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C3AR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD83 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLEC2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COG6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKFZp686O24166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ITM2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB7L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPS27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ATP7A
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Cation_transp_P_typ_ATPase IPR001757 0.08
Category members ATPase_P-typ_transduc_dom_A IPR008250 0.08
Category members HeavyMe-assoc_HMA IPR006121 0
Category members HMA_Cu_ion-bd IPR006122 0
Category members HAD-like_dom IPR023214 0
Category members Cation_transp_P-typ_ATPase_IB IPR027256 0


Protein complexes (CORUM database) featuring ATP7A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ATP7A
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0043085 positive regulation of catalytic activity Database 0.78
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0048813 dendrite morphogenesis Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0001836 release of cytochrome c from mitochondria Database 0.18
Category members GO Category GO:0019829 cation-transporting ATPase activity Database 0.15
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0030141 secretory granule Database 0.11
Category members GO Category GO:0021860 pyramidal neuron development Database 0.11
Category members GO Category GO:0005770 late endosome Database 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0043005 neuron projection Database 0.08
Category members GO Category GO:0031069 hair follicle morphogenesis Database 0.06
Category members GO Category GO:0042415 norepinephrine metabolic process Database 0.04
Category members GO Category GO:0006878 cellular copper ion homeostasis Database 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0030140 trans-Golgi network transport vesicle Database 0.03
Category members GO Category GO:0021954 central nervous system neuron development Database 0.02
Category members GO Category GO:0042428 serotonin metabolic process Database 0.01
Category members GO Category GO:0030199 collagen fibril organization Database 0.01
Category members Pathway Pathway_182 REACTOME_ION_TRANSPORT_BY_P_TYPE_ATPASES 0 0
Category members Pathway Pathway_183 REACTOME_ION_CHANNEL_TRANSPORT 0 0
Category members GO Category GO:0001568 blood vessel development Database 0
Category members GO Category GO:0001974 blood vessel remodeling Database 0
Category members GO Category GO:0002082 regulation of oxidative phosphorylation Database 0
Category members GO Category GO:0004008 copper-exporting ATPase activity Database 0
Category members GO Category GO:0005375 copper ion transmembrane transporter activity Database 0
Category members GO Category GO:0005507 copper ion binding Database 0
Category members GO Category GO:0006568 tryptophan metabolic process Database 0
Category members GO Category GO:0006570 tyrosine metabolic process Database 0
Category members GO Category GO:0006584 catecholamine metabolic process Database 0
Category members GO Category GO:0006812 cation transport Database 0
Category members GO Category GO:0006825 copper ion transport Database 0
Category members GO Category GO:0007005 mitochondrion organization Database 0
Category members GO Category GO:0007595 lactation Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0010041 response to iron(III) ion Database 0
Category members GO Category GO:0010043 response to zinc ion Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0015677 copper ion import Database 0
Category members GO Category GO:0016532 superoxide dismutase copper chaperone activity Database 0
Category members GO Category GO:0018205 peptidyl-lysine modification Database 0
Category members GO Category GO:0019430 removal of superoxide radicals Database 0
Category members GO Category GO:0021702 cerebellar Purkinje cell differentiation Database 0
Category members GO Category GO:0030001 metal ion transport Database 0
Category members GO Category GO:0031410 cytoplasmic vesicle Database 0
Category members GO Category GO:0031526 brush border membrane Database 0
Category members GO Category GO:0032767 copper-dependent protein binding Database 0
Category members GO Category GO:0034220 ion transmembrane transport Database 0
Category members GO Category GO:0042093 T-helper cell differentiation Database 0
Category members GO Category GO:0042417 dopamine metabolic process Database 0
Category members GO Category GO:0042421 norepinephrine biosynthetic process Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043473 pigmentation Database 0
Category members GO Category GO:0043588 skin development Database 0
Category members GO Category GO:0046034 ATP metabolic process Database 0
Category members GO Category GO:0046688 response to copper ion Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048251 elastic fiber assembly Database 0
Category members GO Category GO:0048286 lung alveolus development Database 0
Category members GO Category GO:0048554 positive regulation of metalloenzyme activity Database 0
Category members GO Category GO:0048812 neuron projection morphogenesis Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0051353 positive regulation of oxidoreductase activity Database 0
Category members GO Category GO:0060003 copper ion export Database 0


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