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Query: ATP5B

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ATP5B 1 -2.457 2.320 -1.410 0.568 0.424 -1.201

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ATP5B Ubiquitylation K426 -0.601 _GVQK(gl)ILQDYK_
ATP5B Phosphorylation S465 -1.223 _FLS(ph)QPFQVAEVFTGHMGK_
ATP5B Ubiquitylation K55 -1.344 _DYAAQTSPSPK(gl)AGAATGR_

Background Information for ATP5B:


Pubmed-ATP5B »
Uniprot-ATP5B »
Biogrid-ATP5B »
ProteomicsDB-ATP5B »

Tumorportal-ATP5B »
COSMIC-ATP5B »
GenomeRNAi-ATP5B »
Genecards-ATP5B


Protein-protein Interactions for ATP5B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATP2A2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP5A1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CXCR7 Cat. description Hein, Mann, Cell 2015
Category members IP bait FZD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GOLT1B Cat. description Hein, Mann, Cell 2015
Category members IP bait KCNK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MBOAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SACM1L Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait YIPF5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALG10B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP5C1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP5D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP5F1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP5G3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ATP6V0C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait B4GALT3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C3AR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHRM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CTNNA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CXCR7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DNAJC28 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM134C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FPR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPAA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR141 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPRC5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HTR2C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LHFPL4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P2RY12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RELL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait S1PR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SGCZ Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC19A2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC22A12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC27A3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC35F1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC6A5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TACR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TAS2R41 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VIPR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VIPR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFYVE27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ATP5B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members AAA+_ATPase IPR003593 0.38
Category members ATPase_F1/V1/A1_a/bsu_nucl-bd IPR000194 0
Category members ATPase_F1/V1/A1-cplx_a/bsu_C IPR000793 0
Category members ATPase_F1_a/bsu_N IPR004100 0


Protein complexes (CORUM database) featuring ATP5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ATP5B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members Pathway Pathway_50 REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 0 0.7
Category members GO Category GO:0042645 mitochondrial nucleoid Database 0.61
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_9 REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT 0 0.33
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0022904 respiratory electron transport chain Database 0.15
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1) Database 0.05
Category members Pathway Pathway_184 REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING 0 0.04
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0015992 proton transport Database 0.04
Category members GO Category GO:0015986 ATP synthesis coupled proton transport Database 0.01
Category members Pathway Pathway_29 KEGG_ALZHEIMERS_DISEASE 0 0
Category members Pathway Pathway_30 KEGG_OXIDATIVE_PHOSPHORYLATION 0 0
Category members Pathway Pathway_31 KEGG_PARKINSONS_DISEASE 0 0
Category members GO Category GO:0001525 angiogenesis Database 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0005753 mitochondrial proton-transporting ATP synthase complex Database 0
Category members GO Category GO:0006091 generation of precursor metabolites and energy Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006754 ATP biosynthetic process Database 0
Category members GO Category GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration Database 0
Category members GO Category GO:0015991 ATP hydrolysis coupled proton transport Database 0
Category members GO Category GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances Database 0
Category members GO Category GO:0022857 transmembrane transporter activity Database 0
Category members GO Category GO:0031966 mitochondrial membrane Database 0
Category members GO Category GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain Database 0
Category members GO Category GO:0042288 MHC class I protein binding Database 0
Category members GO Category GO:0042776 mitochondrial ATP synthesis coupled proton transport Database 0
Category members GO Category GO:0046034 ATP metabolic process Database 0
Category members GO Category GO:0046933 proton-transporting ATP synthase activity, rotational mechanism Database 0
Category members GO Category GO:0046961 proton-transporting ATPase activity, rotational mechanism Database 0
Category members GO Category GO:0051453 regulation of intracellular pH Database 0


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