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Query: APLP2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
APLP2 0 -0.804 -0.080 0.400

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
APLP2 Ubiquitylation K744 -1.204 _HLNK(gl)M(ox)QNHGYENPTYK_

Background Information for APLP2:


Pubmed-APLP2 »
Uniprot-APLP2 »
Biogrid-APLP2 »
ProteomicsDB-APLP2 »

Tumorportal-APLP2 »
COSMIC-APLP2 »
GenomeRNAi-APLP2 »
Genecards-APLP2


Protein-protein Interactions for APLP2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GPKOW Cat. description Hein, Mann, Cell 2015
Category members IP bait APBA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait APBB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DKKL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FCGRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in APLP2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Amyloid_glyco_extra IPR008154 0.26
Category members Amyloid_glyco IPR008155 0.26
Category members Amyloid_glyco_Cu-bd IPR011178 0.26
Category members Amyloid_glyco_heparin-bd IPR015849 0.26
Category members APP_amyloid_C IPR019543 0.26
Category members Amyloid_glyco_E2_domain IPR024329 0.26
Category members Prot_inh_Kunz-m IPR002223 0.05


Protein complexes (CORUM database) featuring APLP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring APLP2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0007186 G-protein coupled receptor signaling pathway Database 1.53
Category members GO Category GO:0004867 serine-type endopeptidase inhibitor activity Database 1.42
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0008201 heparin binding Database 0.27
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046914 transition metal ion binding Database 0.26
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0001967 suckling behavior Database 0.05
Category members GO Category GO:0043393 regulation of protein binding Database 0.04
Category members GO Category GO:0006878 cellular copper ion homeostasis Database 0.04
Category members GO Category GO:0050885 neuromuscular process controlling balance Database 0.02
Category members GO Category GO:0007617 mating behavior Database 0.01
Category members GO Category GO:0007176 regulation of epidermal growth factor-activated receptor activity Database 0
Category members GO Category GO:0007626 locomotory behavior Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0030901 midbrain development Database 0


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