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Query: AP2S1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AP2S1 0 1.236 -0.210 0.500 -0.049 0.539 0.830 0.375

PTM Sites:

Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AP2S1 Ubiquitylation K130 -1.793 0.099 _ETSQTK(gl)VLK_
AP2S1 Ubiquitylation K45 -1.058 -0.297 _DAK(gl)HTNFVEFR_

Background Information for AP2S1:





Protein-protein Interactions for AP2S1

Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMO Cat. description Hein, Mann, Cell 2015
Category members IP bait AMPH Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AP2S1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARFGAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RUNDC3A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in AP2S1

Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Longin-like_dom IPR011012 0.34
Category members AP_complex_ssu IPR016635 0.31
Category members AP_mu_sigma_su IPR022775 0.25


Protein complexes (CORUM database) featuring AP2S1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring AP2S1

Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0006886 intracellular protein transport Database 2.48
Category members Pathway Pathway_259 REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 0 2.34
Category members Pathway Pathway_221 REACTOME_SIGNALLING_BY_NGF 0 2.14
Category members Pathway Pathway_258 REACTOME_SIGNALING_BY_EGFR_IN_CANCER 0 1.81
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members Pathway Pathway_666 KEGG_ENDOCYTOSIS 0 1.25
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_809 REACTOME_EGFR_DOWNREGULATION 0 1.1
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_195 REACTOME_NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS 0 1.08
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_194 REACTOME_THE_ROLE_OF_NEF_IN_HIV1_REPLICATION_AND_DISEASE_PATHOGENESIS 0 0.83
Category members GO Category GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway Database 0.64
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0050690 regulation of defense response to virus by virus Database 0.49
Category members Pathway Pathway_32 KEGG_HUNTINGTONS_DISEASE 0 0.46
Category members Pathway Pathway_1076 REACTOME_SIGNAL_TRANSDUCTION_BY_L1 0 0.44
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0008565 protein transporter activity Database 0.26
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0030122 AP-2 adaptor complex Database 0.19
Category members Pathway Pathway_1011 REACTOME_TRAFFICKING_OF_AMPA_RECEPTORS 0 0.18
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members Pathway Pathway_1155 REACTOME_TRAFFICKING_OF_GLUR2_CONTAINING_AMPA_RECEPTORS 0 0.13
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0030666 endocytic vesicle membrane Database 0.08
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members Pathway Pathway_1146 REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING 0 0
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_230 REACTOME_NEUROTRANSMITTER_RECEPTOR_BINDING_AND_DOWNSTREAM_TRANSMISSION_IN_THE_POSTSYNAPTIC_CELL 0 0
Category members GO Category GO:0005215 transporter activity Database 0
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0030100 regulation of endocytosis Database 0
Category members GO Category GO:0030117 membrane coat Database 0
Category members GO Category GO:0030669 clathrin-coated endocytic vesicle membrane Database 0
Category members GO Category GO:0048268 clathrin coat assembly Database 0


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