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Query: AGO2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
AGO2 1 1.171 0.370 -0.620 0.303 -0.277 -0.950 0.328

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
AGO2 Ubiquitylation K550 0.445 1.991 _VGDTVLGMATQCVQMK(gl)NVQR_
AGO2 Ubiquitylation K726 0.458 0.936 _VGK(gl)SGNIPAGTTVDTK_
AGO2 Ubiquitylation K720 -1.047 0.670 _LFCTDK(gl)NER_
AGO2 Ubiquitylation K381 0.665 _SAPDRQEEISK(gl)LMR_
AGO2 Phosphorylation S387 -0.656 _SAS(ph)FNTDPYVR_

Background Information for AGO2:


Pubmed-AGO2 »
Uniprot-AGO2 »
Biogrid-AGO2 »
ProteomicsDB-AGO2 »

Tumorportal-AGO2 »
COSMIC-AGO2 »
GenomeRNAi-AGO2 »
Genecards-AGO2


Protein-protein Interactions for AGO2
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in AGO2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PAZ_dom IPR003100 0.15
Category members DUF1785 IPR014811 0.11
Category members Piwi IPR003165 0.05
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring AGO2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5360 AGO2-FXR1-TNF(alpha)ARE-RNP complex Database 0.04
Category members Corum 1385 DICER1-NCOA6-AGO2 complex Database 0
Category members Corum 1387 TTP-AGO2 complex Database 0
Category members Corum 3032 RNA-induced silencing complex, RISC Database 0
Category members Corum 5377 RNA-induced silencing complex, RISC Database 0
Category members Corum 5378 TRBP containing complex (DICER, TRBP, AGO2, RPL7A, EIF6, MOV10) Database 0
Category members Corum 5381 RNA-induced silencing complex, RISC Database 0


Categories featuring AGO2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members GO Category GO:0048011 neurotrophin TRK receptor signaling pathway Database 0.63
Category members GO Category GO:0038095 Fc-epsilon receptor signaling pathway Database 0.36
Category members GO Category GO:0008543 fibroblast growth factor receptor signaling pathway Database 0.29
Category members GO Category GO:0007173 epidermal growth factor receptor signaling pathway Database 0.26
Category members GO Category GO:0035197 siRNA binding Database 0.23
Category members GO Category GO:0016442 RISC complex Database 0.18
Category members GO Category GO:0035068 micro-ribonucleoprotein complex Database 0.11
Category members GO Category GO:0005844 polysome Database 0.09
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0035279 mRNA cleavage involved in gene silencing by miRNA Database 0.04
Category members GO Category GO:0031054 pre-miRNA processing Database 0.01
Category members GO Category GO:0000340 RNA 7-methylguanosine cap binding Database 0
Category members GO Category GO:0004521 endoribonuclease activity Database 0
Category members GO Category GO:0005845 mRNA cap binding complex Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0006379 mRNA cleavage Database 0
Category members GO Category GO:0009791 post-embryonic development Database 0
Category members GO Category GO:0031047 gene silencing by RNA Database 0
Category members GO Category GO:0035198 miRNA binding Database 0
Category members GO Category GO:0035278 negative regulation of translation involved in gene silencing by miRNA Database 0
Category members GO Category GO:0045947 negative regulation of translational initiation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Database 0


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