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negative regulation of translational initiation
(GO:0045947)

RNAi screen result RNAPII IP (MG132) CSB IP CSB IP (MG132) Chrom. Chrom. (MG132) Ubi /Phospo Ubi /Phospho (MG132)
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Protein Results:

 Results for post-translational modifications (below)
Gene name MGoogle Score RNAi high RNAi low RNAPII-IP (MG132) CSB-IP CSB-IP (MG132) Chrom. Chrom. (MG132)
TPR 3 -1.680 3.070 0.483 -1.104 0.827 0.514
EIF3E 1 0.730 -0.450 0.344 0.334
EIF3E 1 0.730 -0.450 1.131 -0.262 -0.898
AGO2 1 0.370 -0.620 0.303 -0.277 -0.950 0.328
EIF4EBP1 1 2.050 -1.320
EIF2B4 0 -0.600 0.760 -1.449 -0.595 0.243
PAIP2 0 0.500 -1.210
EIF4EBP2 0 1.140 -0.720
RBM4 0 -0.070 0.200 0.658 0.120
RBM4 0 -0.070 0.200 -0.149 0.399 0.199

PTM Sites:

 Back to Protein Results
Gene name PTM type PTM site UV UV (MG132) Sequence
AGO2 Ubiquitylation K381 0.665 _SAPDRQEEISK(gl)LMR_
AGO2 Phosphorylation S387 -0.656 _SAS(ph)FNTDPYVR_
AGO2 Ubiquitylation K550 0.445 1.991 _VGDTVLGMATQCVQMK(gl)NVQR_
AGO2 Ubiquitylation K720 -1.047 0.670 _LFCTDK(gl)NER_
AGO2 Ubiquitylation K726 0.458 0.936 _VGK(gl)SGNIPAGTTVDTK_
EIF2B4 Phosphorylation S21 1.059 _SLS(ph)GSLCALFSDADSGSGM(ox)K_
EIF2B4 Phosphorylation S151 -1.351 -1.042 _KGEQGGPPPKAS(ph)PSTAGETPSGVK_
EIF3E Ubiquitylation K93 -1.262 _QLQAETEPIVK(gl)MFEDPETTR_
EIF3E Ubiquitylation K265 0.383 _YLTTAVITNK(gl)DVR_
EIF3E Ubiquitylation K275 0.354 _QVLK(gl)DLVK_
EIF3E Ubiquitylation K383 -0.383 0.200 _LDAK(gl)IDSK_
EIF3E Ubiquitylation K387 -1.539 _IDSK(gl)LGHVVMGNNAVSPYQQVIEK_
EIF3E Phosphorylation S399 0.511 -0.527 _LGHVVMGNNAVS(ph)PYQQVIEK_
EIF3E Ubiquitylation K409 0.985 2.077 _TK(gl)SLSFR_
EIF3E Ubiquitylation K424 -0.366 _SQMLAMNIEK(gl)K_
EIF3E Ubiquitylation K425 -0.382 0.649 _SQMLAMNIEKK(gl)_
EIF4EBP1 Phosphorylation Y34 -1.060 _RVVLGDGVQLPPGDY(ph)STTPGGTLFS(ph)TTPGGTR_
EIF4EBP1 Phosphorylation S35 -0.849 _RVVLGDGVQLPPGDYS(ph)TTPGGTLFS(ph)TTPGGTR_
EIF4EBP1 Phosphorylation T37 -0.768 -0.583 _RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR_
EIF4EBP1 Phosphorylation T41 -3.655 -0.903 _RVVLGDGVQLPPGDYST(ph)TPGGT(ph)LFSTTPGGTR_
EIF4EBP1 Phosphorylation S44 -0.796 _VVLGDGVQLPPGDYSTTPGGTLFS(ph)T(ph)TPGGTR_
EIF4EBP1 Phosphorylation T45 -0.727 _VVLGDGVQLPPGDYSTTPGGTLFS(ph)T(ph)TPGGTR_
EIF4EBP1 Phosphorylation T46 -0.890 -0.817 _RVVLGDGVQLPPGDYSTT(ph)PGGTLFSTT(ph)PGGTR_
EIF4EBP1 Phosphorylation S65 0.522 0.478 _NS(ph)PVTKT(ph)PPR_
EIF4EBP1 Phosphorylation T68 -1.621 -2.402 _NS(ph)PVT(ph)KTPPRDLPTIPGVTSPSSDEPPMEASQSHLR_
EIF4EBP1 Ubiquitylation K69 -1.171 -1.547 _NSPVTK(gl)TPPR_
EIF4EBP1 Phosphorylation T70 -0.702 -0.017 _NSPVTKT(ph)PPR_
EIF4EBP1 Phosphorylation T77 -1.921 -1.898 _TPPRDLPT(ph)IPGVTSPSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation T82 1.253 _DLPTIPGVT(ph)SPSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation S83 1.211 0.339 _DLPTIPGVTS(ph)PSSDEPPMEASQSHLR_
EIF4EBP1 Phosphorylation S96 -1.541 _DLPTIPGVTSPSSDEPPMEASQS(ph)HLRNSPEDK_
EIF4EBP1 Phosphorylation S101 -1.900 -1.976 _DLPTIPGVTSPSSDEPPMEASQSHLRNS(ph)PEDK_
EIF4EBP2 Phosphorylation Y34 -0.496 -0.320 _TVAISDAAQLPHDY(ph)CTTPGGTLFSTT(ph)PGGTR_
EIF4EBP2 Phosphorylation T37 -0.389 -0.339 _TVAISDAAQLPHDYCTT(ph)PGGTLFST(ph)TPGGTR_
EIF4EBP2 Phosphorylation T41 -0.111 _TVAISDAAQLPHDYCTTPGGT(ph)LFST(ph)TPGGTR_
EIF4EBP2 Phosphorylation T45 -0.113 _TVAISDAAQLPHDYCTTPGGT(ph)LFST(ph)TPGGTR_
EIF4EBP2 Phosphorylation T46 -0.240 -0.084 _TVAISDAAQLPHDYCTTPGGTLFSTT(ph)PGGTR_
PAIP2 Ubiquitylation K123 -2.257 _EFVPGVK(gl)YGNI_
RBM4 Phosphorylation S86 0.208 0.329 _LHVGNIS(ph)PTCTNK_
RBM4 Phosphorylation T88 0.272 0.180 _LHVGNISPT(ph)CTNK_
RBM4 Ubiquitylation K92 -1.041 _LHVGNISPTCTNK(gl)ELR_
RBM4 Ubiquitylation K139 0.371 0.223 _GLDNTEFQGK(gl)R_
TPR Ubiquitylation K40 -0.506 -0.355 _FLADQQSEIDGLK(gl)GR_
TPR Ubiquitylation K146 -0.069 0.593 _LSQELEYLTEDVK(gl)R_
TPR Ubiquitylation K177 -1.953 _LDELQASDVSVK(gl)YR_
TPR Ubiquitylation K290 -0.496 -0.246 _LSNLYK(gl)SAADDSEAK_
TPR Ubiquitylation K312 0.319 _AVEELHK(gl)LLK_
TPR Ubiquitylation K315 -0.400 _LLK(gl)EAGEANK_
TPR Ubiquitylation K364 0.423 -0.115 _ELENANDLLSATK(gl)R_
TPR Ubiquitylation K366 -0.723 _K(gl)GAILSEEELAAMSPTAAAVAK_
TPR Phosphorylation S379 1.008 0.645 _GAILSEEELAAMS(ph)PTAAAVAK_
TPR Phosphorylation T381 0.606 _GAILSEEELAAMSPT(ph)AAAVAK_
TPR Ubiquitylation K390 -0.363 _IVK(gl)PGMK_
TPR Ubiquitylation K433 -0.890 -0.961 _EVEAK(gl)APILK_
TPR Ubiquitylation K449 0.226 -0.444 _AQK(gl)AVASLSVK_
TPR Ubiquitylation K463 -0.204 0.730 _LEQAMK(gl)EIQR_
TPR Ubiquitylation K474 -0.552 -0.279 _LQEDTDK(gl)ANKQSSVLER_
TPR Ubiquitylation K477 -0.752 -0.279 _LQEDTDKANK(gl)QSSVLER_
TPR Ubiquitylation K494 -0.348 -0.293 _RMEIQVK(gl)DLSQQIR_
TPR Ubiquitylation K575 -1.583 -1.014 _EREEQETTSSK(gl)ITELQLK_
TPR Ubiquitylation K713 -0.471 -0.123 _SQNTK(gl)ISTQLDFASK_
TPR Ubiquitylation K723 -0.427 _ISTQLDFASK(gl)R_
TPR Ubiquitylation K773 -1.379 _GANEK(gl)LAVAEVR_
TPR Ubiquitylation K877 -0.998 0.155 _NLDVQLLDTK(gl)R_
TPR Ubiquitylation K895 -0.147 -0.704 _ELLK(gl)NAQK_
TPR Ubiquitylation K931 -0.202 -0.484 _GQPSNK(gl)EDVDDLVSQLR_
TPR Ubiquitylation K952 0.559 0.228 _QTEEQVNDLK(gl)ER_
TPR Ubiquitylation K1081 -1.092 _IAVEAQNK(gl)YER_
TPR Ubiquitylation K1105 0.414 -0.260 _EQVSK(gl)MASVR_
TPR Ubiquitylation K1144 -1.114 _MLKDEVSK(gl)CVCR_
TPR Phosphorylation S1185 -0.321 -0.495 _EGVQGPLNVS(ph)LSEEGK_
TPR Ubiquitylation K1326 -0.405 _SGMLQAEKK(gl)_
TPR Ubiquitylation K1400 0.630 _SNASLTNNQNLIQSLK(gl)EDLNK_
TPR Ubiquitylation K1429 0.511 _VK(gl)TITQVK_
TPR Ubiquitylation K1491 0.233 _SK(gl)SLESQVENLQK_
TPR Ubiquitylation K1670 -2.992 _GIASTSDPPTANIK(gl)PTPVVSTPSK_
TPR Ubiquitylation K1690 0.188 1.291 _VTAAAMAGNK(gl)STPR_
TPR Phosphorylation S2034 1.700 2.036 _AADS(ph)QNSGEGNTGAAESSFSQEVSR_
TPR Phosphorylation S2037 0.660 _AADSQNS(ph)GEGNTGAAESSFSQEVSR_
TPR Phosphorylation S2048 0.701 _AADSQNSGEGNTGAAESS(ph)FSQEVSR_
TPR Phosphorylation S2050 0.764 1.393 _AADSQNSGEGNTGAAESSFS(ph)QEVSR_
TPR Phosphorylation T2116 -0.625 -2.789 _GLQLT(ph)PGIGGMQQHFFDDEDR_
TPR Phosphorylation S2155 0.926 -2.294 _TDGFAEAIHS(ph)PQVAGVPR_


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