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Query: EIF3E

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
EIF3E 1 3.695 0.730 -0.450 0.344 0.334
EIF3E 1 3.695 0.730 -0.450 1.131 -0.262 -0.898

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
EIF3E Ubiquitylation K409 0.985 2.077 _TK(gl)SLSFR_
EIF3E Ubiquitylation K425 -0.382 0.649 _SQMLAMNIEKK(gl)_
EIF3E Ubiquitylation K265 0.383 _YLTTAVITNK(gl)DVR_
EIF3E Ubiquitylation K275 0.354 _QVLK(gl)DLVK_
EIF3E Ubiquitylation K383 -0.383 0.200 _LDAK(gl)IDSK_
EIF3E Phosphorylation S399 0.511 -0.527 _LGHVVMGNNAVS(ph)PYQQVIEK_
EIF3E Ubiquitylation K93 -1.262 _QLQAETEPIVK(gl)MFEDPETTR_
EIF3E Ubiquitylation K387 -1.539 _IDSK(gl)LGHVVMGNNAVSPYQQVIEK_
EIF3E Ubiquitylation K424 -0.366 _SQMLAMNIEK(gl)K_

Background Information for EIF3E:


Pubmed-EIF3E »
Uniprot-EIF3E »
Biogrid-EIF3E »
ProteomicsDB-EIF3E »

Tumorportal-EIF3E »
COSMIC-EIF3E »
GenomeRNAi-EIF3E »
Genecards-EIF3E


Protein-protein Interactions for EIF3E
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EIF3A Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3E Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3I Cat. description Hein, Mann, Cell 2015
Category members IP bait ITSN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NPM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL10 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPL35 Cat. description Hein, Mann, Cell 2015
Category members IP bait RRBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EIF3F Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3H Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3I Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF3M Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EIF4A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPBP1L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RSPH9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in EIF3E
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PCI_dom IPR000717 2.22


Protein complexes (CORUM database) featuring EIF3E
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 742 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7) Database 1.74
Category members Corum 1097 eIF3 complex (EIF3S6, EIF3S5, EIF3S4, EIF3S3, EIF3S6IP, EIF3S2, EIF3S9, EIF3S12, EIF3S10, EIF3S8, EIF3S1, EIF3S7, PCID1) Database 1.41


Categories featuring EIF3E
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_769 REACTOME_FORMATION_OF_THE_TERNARY_COMPLEX_AND_SUBSEQUENTLY_THE_43S_COMPLEX 0 INF
Category members Pathway Pathway_774 REACTOME_3_UTR_MEDIATED_TRANSLATIONAL_REGULATION 0 INF
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006413 translational initiation Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members Pathway Pathway_775 REACTOME_ACTIVATION_OF_THE_MRNA_UPON_BINDING_OF_THE_CAP_BINDING_COMPLEX_AND_EIFS_AND_SUBSEQUENT_BINDING_TO_43S 0 11.53
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0005852 eukaryotic translation initiation factor 3 complex Database 2.27
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0033290 eukaryotic 48S preinitiation complex Database 1.41
Category members GO Category GO:0016605 PML body Database 1.41
Category members GO Category GO:0001731 formation of translation preinitiation complex Database 1.15
Category members GO Category GO:0016282 eukaryotic 43S preinitiation complex Database 1.15
Category members GO Category GO:0003743 translation initiation factor activity Database 0.71
Category members Pathway Pathway_762 PID_HIF2PATHWAY 0 0.23
Category members GO Category GO:0006446 regulation of translational initiation Database 0.04
Category members GO Category GO:0045947 negative regulation of translational initiation Database 0


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