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Query: TPR

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TPR 3 10.551 -1.680 3.070 0.483 -1.104 0.827 0.514

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TPR Phosphorylation S2034 1.700 2.036 _AADS(ph)QNSGEGNTGAAESSFSQEVSR_
TPR Phosphorylation S2050 0.764 1.393 _AADSQNSGEGNTGAAESSFS(ph)QEVSR_
TPR Ubiquitylation K1690 0.188 1.291 _VTAAAMAGNK(gl)STPR_
TPR Ubiquitylation K463 -0.204 0.730 _LEQAMK(gl)EIQR_
TPR Phosphorylation S2037 0.660 _AADSQNS(ph)GEGNTGAAESSFSQEVSR_
TPR Phosphorylation S379 1.008 0.645 _GAILSEEELAAMS(ph)PTAAAVAK_
TPR Phosphorylation T381 0.606 _GAILSEEELAAMSPT(ph)AAAVAK_
TPR Ubiquitylation K146 -0.069 0.593 _LSQELEYLTEDVK(gl)R_
TPR Ubiquitylation K952 0.559 0.228 _QTEEQVNDLK(gl)ER_
TPR Ubiquitylation K877 -0.998 0.155 _NLDVQLLDTK(gl)R_
TPR Ubiquitylation K364 0.423 -0.115 _ELENANDLLSATK(gl)R_
TPR Ubiquitylation K713 -0.471 -0.123 _SQNTK(gl)ISTQLDFASK_
TPR Ubiquitylation K290 -0.496 -0.246 _LSNLYK(gl)SAADDSEAK_
TPR Ubiquitylation K1105 0.414 -0.260 _EQVSK(gl)MASVR_
TPR Ubiquitylation K474 -0.552 -0.279 _LQEDTDK(gl)ANKQSSVLER_
TPR Ubiquitylation K477 -0.752 -0.279 _LQEDTDKANK(gl)QSSVLER_
TPR Ubiquitylation K494 -0.348 -0.293 _RMEIQVK(gl)DLSQQIR_
TPR Ubiquitylation K40 -0.506 -0.355 _FLADQQSEIDGLK(gl)GR_
TPR Ubiquitylation K449 0.226 -0.444 _AQK(gl)AVASLSVK_
TPR Ubiquitylation K931 -0.202 -0.484 _GQPSNK(gl)EDVDDLVSQLR_
TPR Phosphorylation S1185 -0.321 -0.495 _EGVQGPLNVS(ph)LSEEGK_
TPR Ubiquitylation K895 -0.147 -0.704 _ELLK(gl)NAQK_
TPR Ubiquitylation K433 -0.890 -0.961 _EVEAK(gl)APILK_
TPR Ubiquitylation K575 -1.583 -1.014 _EREEQETTSSK(gl)ITELQLK_
TPR Phosphorylation S2155 0.926 -2.294 _TDGFAEAIHS(ph)PQVAGVPR_
TPR Phosphorylation T2116 -0.625 -2.789 _GLQLT(ph)PGIGGMQQHFFDDEDR_
TPR Ubiquitylation K177 -1.953 _LDELQASDVSVK(gl)YR_
TPR Ubiquitylation K312 0.319 _AVEELHK(gl)LLK_
TPR Ubiquitylation K315 -0.400 _LLK(gl)EAGEANK_
TPR Ubiquitylation K366 -0.723 _K(gl)GAILSEEELAAMSPTAAAVAK_
TPR Ubiquitylation K390 -0.363 _IVK(gl)PGMK_
TPR Ubiquitylation K723 -0.427 _ISTQLDFASK(gl)R_
TPR Ubiquitylation K773 -1.379 _GANEK(gl)LAVAEVR_
TPR Ubiquitylation K1081 -1.092 _IAVEAQNK(gl)YER_
TPR Ubiquitylation K1144 -1.114 _MLKDEVSK(gl)CVCR_
TPR Ubiquitylation K1326 -0.405 _SGMLQAEKK(gl)_
TPR Ubiquitylation K1400 0.630 _SNASLTNNQNLIQSLK(gl)EDLNK_
TPR Ubiquitylation K1429 0.511 _VK(gl)TITQVK_
TPR Ubiquitylation K1491 0.233 _SK(gl)SLESQVENLQK_
TPR Ubiquitylation K1670 -2.992 _GIASTSDPPTANIK(gl)PTPVVSTPSK_
TPR Phosphorylation S2048 0.701 _AADSQNSGEGNTGAAESS(ph)FSQEVSR_

Background Information for TPR:


Pubmed-TPR »
Uniprot-TPR »
Biogrid-TPR »
ProteomicsDB-TPR »

Tumorportal-TPR »
COSMIC-TPR »
GenomeRNAi-TPR »
Genecards-TPR


Protein-protein Interactions for TPR
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KATNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP107 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP153 Cat. description Hein, Mann, Cell 2015
Category members IP bait NUP98 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZC3HC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TPR
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members tRNA-bd_arm IPR010978 0.08
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring TPR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TPR
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_371 REACTOME_INFLUENZA_LIFE_CYCLE 0 INF
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_374 REACTOME_LATE_PHASE_OF_HIV_LIFE_CYCLE 0 7.57
Category members Pathway Pathway_1310 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS 0 7.24
Category members Pathway Pathway_1311 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY 0 7.24
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members Pathway Pathway_1206 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS 0 6.87
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members Pathway Pathway_886 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT 0 5.93
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0010827 regulation of glucose transport Database 5.83
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_120 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN 0 5.24
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_887 REACTOME_METABOLISM_OF_NON_CODING_RNA 0 4.38
Category members GO Category GO:0008645 hexose transport Database 4.15
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_98 REACTOME_GLUCOSE_TRANSPORT 0 3.58
Category members Pathway Pathway_689 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 0 3.51
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0015758 glucose transport Database 2.09
Category members GO Category GO:0006606 protein import into nucleus Database 1.81
Category members GO Category GO:0031072 heat shock protein binding Database 1.59
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0044615 nuclear pore nuclear basket Database 1.35
Category members GO Category GO:0034399 nuclear periphery Database 1.34
Category members Pathway Pathway_699 REACTOME_INTERFERON_SIGNALING 0 0.86
Category members GO Category GO:0015631 tubulin binding Database 0.83
Category members GO Category GO:0042405 nuclear inclusion body Database 0.82
Category members GO Category GO:0005487 nucleocytoplasmic transporter activity Database 0.79
Category members Disease phenotype THYROID_CARCINOMA_PAPILLARY THYROID CARCINOMA PAPILLARY Database 0.72
Category members GO Category GO:0007094 mitotic spindle assembly checkpoint Database 0.68
Category members GO Category GO:0019221 cytokine-mediated signaling pathway Database 0.44
Category members GO Category GO:0006999 nuclear pore organization Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046832 negative regulation of RNA export from nucleus Database 0.34
Category members Pathway Pathway_505 REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 0 0.33
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0004828 serine-tRNA ligase activity Database 0.25
Category members GO Category GO:0006434 seryl-tRNA aminoacylation Database 0.25
Category members GO Category GO:0006405 RNA export from nucleus Database 0.24
Category members Pathway Pathway_96 REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT 0 0.23
Category members GO Category GO:0034605 cellular response to heat Database 0.18
Category members GO Category GO:0051019 mitogen-activated protein kinase binding Database 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members Disease phenotype Papillary_or_follicular_thyroid_carcinoma Papillary or follicular thyroid carcinoma Database 0.09
Category members Pathway Pathway_99 REACTOME_TRANSMEMBRANE_TRANSPORT_OF_SMALL_MOLECULES 0 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0070840 dynein complex binding Database 0.04
Category members GO Category GO:0046827 positive regulation of protein export from nucleus Database 0.03
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_24 KEGG_PATHWAYS_IN_CANCER 0 0
Category members Pathway Pathway_944 KEGG_THYROID_CANCER 0 0
Category members GO Category GO:0000189 MAPK import into nucleus Database 0
Category members GO Category GO:0005868 cytoplasmic dynein complex Database 0
Category members GO Category GO:0019898 extrinsic to membrane Database 0
Category members GO Category GO:0035457 cellular response to interferon-alpha Database 0
Category members GO Category GO:0042307 positive regulation of protein import into nucleus Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0045947 negative regulation of translational initiation Database 0
Category members GO Category GO:0070849 response to epidermal growth factor Database 0


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