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Query: ACVR1B

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
ACVR1B 0 1.030 -0.720 1.030

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
ACVR1B Ubiquitylation K215 0.000 _TIVLQEIIGK(gl)GR_

Background Information for ACVR1B:


Pubmed-ACVR1B »
Uniprot-ACVR1B »
Biogrid-ACVR1B »
ProteomicsDB-ACVR1B »

Tumorportal-ACVR1B »
COSMIC-ACVR1B »
GenomeRNAi-ACVR1B »
Genecards-ACVR1B


Protein-protein Interactions for ACVR1B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSNAX Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS16 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZBTB48 Cat. description Hein, Mann, Cell 2015
Category members IP bait ZNF644 Cat. description Hein, Mann, Cell 2015
Category members IP bait GPR114 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRAP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in ACVR1B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Activin_rcpt IPR000472 0
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members TGF_beta_rcpt_GS IPR003605 0
Category members ConA-like_lec_gl_sf IPR008985 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring ACVR1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring ACVR1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members Pathway Pathway_448 KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0 2.05
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0045648 positive regulation of erythrocyte differentiation Database 0.23
Category members GO Category GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0030308 negative regulation of cell growth Database 0.18
Category members GO Category GO:0009986 cell surface Database 0.17
Category members GO Category GO:0032924 activin receptor signaling pathway Database 0.17
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0004702 receptor signaling protein serine/threonine kinase activity Database 0.1
Category members GO Category GO:0048185 activin binding Database 0.07
Category members GO Category GO:0016361 activin receptor activity, type I Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway Database 0.04
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_1210 REACTOME_SIGNALING_BY_NODAL 0 0
Category members GO Category GO:0001942 hair follicle development Database 0
Category members GO Category GO:0004675 transmembrane receptor protein serine/threonine kinase activity Database 0
Category members GO Category GO:0005024 transforming growth factor beta-activated receptor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0009966 regulation of signal transduction Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0017002 activin-activated receptor activity Database 0
Category members GO Category GO:0019838 growth factor binding Database 0
Category members GO Category GO:0023014 signal transduction by phosphorylation Database 0
Category members GO Category GO:0032927 positive regulation of activin receptor signaling pathway Database 0
Category members GO Category GO:0034711 inhibin binding Database 0
Category members GO Category GO:0038092 nodal signaling pathway Database 0
Category members GO Category GO:0046332 SMAD binding Database 0
Category members GO Category GO:0046545 development of primary female sexual characteristics Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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