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Query: XRCC4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XRCC4 1 2.744 -0.240 0.070

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XRCC4 Phosphorylation S320 0.439 1.683 _KEHISAENM(ox)S(ph)LETLR_
XRCC4 Phosphorylation S259 -0.552 1.634 _DDSIIS(ph)SLDVTDIAPSR_
XRCC4 Phosphorylation S260 -0.545 1.299 _DDSIISS(ph)LDVTDIAPSR_
XRCC4 Ubiquitylation K178 0.552 _EALETDLYK(gl)R_
XRCC4 Ubiquitylation K197 0.264 _SLHNK(gl)LLNAAQER_

Background Information for XRCC4:


Pubmed-XRCC4 »
Uniprot-XRCC4 »
Biogrid-XRCC4 »
ProteomicsDB-XRCC4 »

Tumorportal-XRCC4 »
COSMIC-XRCC4 »
GenomeRNAi-XRCC4 »
Genecards-XRCC4


Protein-protein Interactions for XRCC4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM60A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FYTTD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF135 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XRCC4
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring XRCC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1189 DNA double-strand break end-joining complex Database 2.16
Category members Corum 336 DNA ligase IV-XRCC4-AHNK complex Database 0.11
Category members Corum 350 DNA ligase IV-XRCC4-PNK complex Database 0
Category members Corum 359 DNA ligase IV-XRCC4-XLF complex Database 0


Categories featuring XRCC4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_376 REACTOME_HIV_LIFE_CYCLE 0 9.45
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0006302 double-strand break repair Database 4.62
Category members Pathway Pathway_861 REACTOME_DOUBLE_STRAND_BREAK_REPAIR 0 4.5
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0010212 response to ionizing radiation Database 1.66
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_859 REACTOME_EARLY_PHASE_OF_HIV_LIFE_CYCLE 0 1.34
Category members GO Category GO:0051103 DNA ligation involved in DNA repair Database 1.31
Category members GO Category GO:0006303 double-strand break repair via nonhomologous end joining Database 0.79
Category members Pathway Pathway_981 REACTOME_INTEGRATION_OF_PROVIRUS 0 0.76
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0070419 nonhomologous end joining complex Database 0.65
Category members Pathway Pathway_860 KEGG_NON_HOMOLOGOUS_END_JOINING 0 0.52
Category members GO Category GO:0033151 V(D)J recombination Database 0.52
Category members GO Category GO:0010332 response to gamma radiation Database 0.52
Category members GO Category GO:0033152 immunoglobulin V(D)J recombination Database 0.46
Category members GO Category GO:0010165 response to X-ray Database 0.32
Category members GO Category GO:0006266 DNA ligation Database 0.27
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0045190 isotype switching Database 0.11
Category members GO Category GO:0050769 positive regulation of neurogenesis Database 0.06
Category members GO Category GO:0048146 positive regulation of fibroblast proliferation Database 0.05
Category members GO Category GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex Database 0.05
Category members Pathway Pathway_967 PID_DNA_PK_PATHWAY 0 0.04
Category members GO Category GO:0033077 T cell differentiation in thymus Database 0.03
Category members GO Category GO:0002328 pro-B cell differentiation Database 0
Category members GO Category GO:0007417 central nervous system development Database 0
Category members GO Category GO:0051351 positive regulation of ligase activity Database 0
Category members GO Category GO:0071285 cellular response to lithium ion Database 0


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