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Query: XRCC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
XRCC1 0 1.213 -0.010 0.060 -0.364 -0.736 -0.059 0.224 0.061

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
XRCC1 Phosphorylation S280 0.316 0.913 _KTPSKPPAQLS(ph)PSVPK_
XRCC1 Phosphorylation S282 0.731 _KTPSKPPAQLS(ph)PSVPK_
XRCC1 Ubiquitylation K143 0.287 0.218 _VK(gl)IVCSQPYSK_
XRCC1 Phosphorylation S475 -0.043 0.033 _AAS(ph)PVLQEDIDIEGVQSEGQDNGAEDSGDTEDELRR_
XRCC1 Phosphorylation T249 -0.792 -0.550 _AIGST(ph)SKPQESPKGK_
XRCC1 Phosphorylation S255 -1.174 -0.626 _AIGSTSKPQES(ph)PK_
XRCC1 Phosphorylation S460 -1.302 -0.863 _TKPTQAAGPS(ph)SPQKPPT(ph)PEETK_
XRCC1 Phosphorylation T467 -1.175 -1.061 _TKPTQAAGPSS(ph)PQKPPT(ph)PEETK_
XRCC1 Phosphorylation S461 -2.007 -4.025 _TKPTQAAGPSS(ph)PQKPPTPEETK_
XRCC1 Ubiquitylation K183 0.349 _VTVTK(gl)LGQFR_
XRCC1 Phosphorylation S240 -1.676 _TSPVTASDPAGPSYAAATLQASSAASSAS(ph)PVSR_
XRCC1 Ubiquitylation K355 0.580 _DK(gl)ALELGAK_
XRCC1 Phosphorylation T471 -1.661 _TKPTQAAGPSS(ph)PQKPPT(ph)PEETK_

Background Information for XRCC1:


Pubmed-XRCC1 »
Uniprot-XRCC1 »
Biogrid-XRCC1 »
ProteomicsDB-XRCC1 »

Tumorportal-XRCC1 »
COSMIC-XRCC1 »
GenomeRNAi-XRCC1 »
Genecards-XRCC1


Protein-protein Interactions for XRCC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDK2AP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCI Cat. description Hein, Mann, Cell 2015
Category members IP bait TPX2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APLF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHD1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H2BA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PCDHB11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XRCC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in XRCC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BRCT_dom IPR001357 1.59
Category members Galactose-bd-like IPR008979 0


Protein complexes (CORUM database) featuring XRCC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 159 Condensin I-PARP-1-XRCC1 complex Database 0.12
Category members Corum 212 DNA ligase III-XRCC1 complex Database 0.05
Category members Corum 363 DNA ligase III-XRCC1 complex Database 0.05
Category members Corum 365 DNA ligase III-XRCC1 complex Database 0.05
Category members Corum 1085 DNA repair complex NEIL2-PNK-Pol(beta)-LigIII(alpha)-XRCC1 Database 0
Category members Corum 1086 DNA repair complex NEIL1-PNK-Pol(beta)-LigIII(alpha)-XRCC1 Database 0
Category members Corum 362 DNA ligase III-XRCC1-PNK-DNA-pol III multiprotein complex Database 0
Category members Corum 5243 XRCC1-LIG3-PNK-TDP1 complex Database 0


Categories featuring XRCC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_338 REACTOME_DNA_REPAIR 0 8.18
Category members GO Category GO:0003684 damaged DNA binding Database 4.54
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0006284 base-excision repair Database 0.04
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_335 REACTOME_BASE_EXCISION_REPAIR 0 0
Category members Pathway Pathway_952 REACTOME_RESOLUTION_OF_AP_SITES_VIA_THE_SINGLE_NUCLEOTIDE_REPLACEMENT_PATHWAY 0 0
Category members GO Category GO:0000012 single strand break repair Database 0
Category members GO Category GO:0001666 response to hypoxia Database 0
Category members GO Category GO:0010033 response to organic substance Database 0
Category members GO Category GO:0021766 hippocampus development Database 0


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