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Query: VCAN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
VCAN 1 4.576 0.760 -0.630

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
VCAN Ubiquitylation K347 3.178 _FDAYCFK(gl)R_
VCAN Ubiquitylation K98 2.161 _IGQDYK(gl)GR_
VCAN Phosphorylation S2130 0.600 0.798 _QEIESETTS(ph)EEQIQEEK_

Background Information for VCAN:


Pubmed-VCAN »
Uniprot-VCAN »
Biogrid-VCAN »
ProteomicsDB-VCAN »

Tumorportal-VCAN »
COSMIC-VCAN »
GenomeRNAi-VCAN »
Genecards-VCAN


Protein-protein Interactions for VCAN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCAN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM19A4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in VCAN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members EG-like_dom IPR000742 1.74
Category members EGF-like_Ca-bd_dom IPR001881 0.69
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members C-type_lectin IPR001304 0.21
Category members Ig_V-set IPR013106 0.09
Category members C-type_lectin_fold IPR016187 0.01
Category members Sushi_SCR_CCP IPR000436 0
Category members Link IPR000538 0
Category members AntifreezeII IPR002353 0


Protein complexes (CORUM database) featuring VCAN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring VCAN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005615 extracellular space Database 4.72
Category members Pathway Pathway_73 REACTOME_GLYCOSAMINOGLYCAN_METABOLISM 0 1.71
Category members GO Category GO:0030203 glycosaminoglycan metabolic process Database 1.44
Category members GO Category GO:0005796 Golgi lumen Database 0.64
Category members Pathway Pathway_471 REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM 0 0.6
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0005578 proteinaceous extracellular matrix Database 0.53
Category members Pathway Pathway_79 REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM 0 0.49
Category members GO Category GO:0031012 extracellular matrix Database 0.45
Category members GO Category GO:0030204 chondroitin sulfate metabolic process Database 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0007275 multicellular organismal development Database 0.31
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members Pathway Pathway_383 PID_P53_DOWNSTREAM_PATHWAY 0 0.23
Category members Pathway Pathway_479 REACTOME_A_TETRASACCHARIDE_LINKER_SEQUENCE_IS_REQUIRED_FOR_GAG_SYNTHESIS 0 0.21
Category members Pathway Pathway_470 REACTOME_CS_DS_DEGRADATION 0 0.11
Category members GO Category GO:0030207 chondroitin sulfate catabolic process Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members GO Category GO:0043202 lysosomal lumen Database 0.07
Category members GO Category GO:0030208 dermatan sulfate biosynthetic process Database 0.04
Category members GO Category GO:0005539 glycosaminoglycan binding Database 0.02
Category members Pathway Pathway_1217 KEGG_CELL_ADHESION_MOLECULES_CAMS 0 0
Category members Pathway Pathway_481 REACTOME_CHONDROITIN_SULFATE_BIOSYNTHESIS 0 0
Category members Pathway Pathway_850 PID_TOLL_ENDOGENOUS_PATHWAY 0 0
Category members GO Category GO:0005540 hyaluronic acid binding Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007507 heart development Database 0
Category members GO Category GO:0008037 cell recognition Database 0
Category members GO Category GO:0008347 glial cell migration Database 0
Category members GO Category GO:0030206 chondroitin sulfate biosynthetic process Database 0
Category members GO Category GO:0030246 carbohydrate binding Database 0


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