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Query: UPF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
UPF1 0 -0.052 -0.362 -0.954 -0.781 -0.966 -0.333

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
UPF1 Ubiquitylation K790 0.647 0.880 _ITTK(gl)LLK_
UPF1 Phosphorylation S1107 0.100 0.763 _SQIDVALS(ph)QDSTYQGER_
UPF1 Ubiquitylation K321 0.611 _LK(gl)ESQTQDNITVR_
UPF1 Ubiquitylation K638 -2.024 -0.456 _LAK(gl)MQFR_
UPF1 Ubiquitylation K340 -1.693 _WDLGLNKK(gl)_
UPF1 Ubiquitylation K378 -1.658 _YK(gl)GDLAPLWK_
UPF1 Ubiquitylation K793 -2.075 _LLK(gl)AGAKPDQIGIITPYEGQR_

Background Information for UPF1:


Pubmed-UPF1 »
Uniprot-UPF1 »
Biogrid-UPF1 »
ProteomicsDB-UPF1 »

Tumorportal-UPF1 »
COSMIC-UPF1 »
GenomeRNAi-UPF1 »
Genecards-UPF1


Protein-protein Interactions for UPF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CNOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELAVL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait OAZ1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SORT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SUMO3 Cat. description Hein, Mann, Cell 2015
Category members IP bait TAOK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait UPF3B Cat. description Hein, Mann, Cell 2015
Category members IP bait APOBEC3D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGCR8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait E4F1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ELAVL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GLTSCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GSPT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait H2AFX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1T Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HNRNPA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ILF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MEMO1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MKI67IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NSA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPAN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRDM5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRR11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAU1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STRBP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRA2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait WDR46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3H18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3H3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3HAV1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZCRB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFC3H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF576 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in UPF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase/UvrB_dom IPR006935 0.78


Protein complexes (CORUM database) featuring UPF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 822 mRNA decay complex (UPF1, UPF2, UPF3B, DCP2, XRN1, XRN2, EXOSC2, EXOSC4, EXOSC10, PARN) Database 1.39
Category members Corum 812 Upf complex (UPF1, UPF2, UPF3a) Database 0.26
Category members Corum 813 Upf complex (UPF1, UPF2, UPF3b) Database 0.26
Category members Corum 784 SMG-1-Upf1-eRF1-eRF3 complex (SURF) Database 0.08
Category members Corum 814 Postsplicing complex Database 0.01


Categories featuring UPF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Database INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0004004 ATP-dependent RNA helicase activity Database 1.43
Category members GO Category GO:0071044 histone mRNA catabolic process Database 0.35
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0035145 exon-exon junction complex Database 0.28
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0044530 supraspliceosomal complex Database 0.08
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members GO Category GO:0006449 regulation of translational termination Database 0
Category members GO Category GO:0009048 dosage compensation by inactivation of X chromosome Database 0


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