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Query: TYRO3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TYRO3 0 0.715 0.220 -0.340

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TYRO3 Phosphorylation S930 0.766 -0.051 _YILTPGGLAEQPGQAEHQPES(ph)PLNETQR_

Background Information for TYRO3:


Pubmed-TYRO3 »
Uniprot-TYRO3 »
Biogrid-TYRO3 »
ProteomicsDB-TYRO3 »

Tumorportal-TYRO3 »
COSMIC-TYRO3 »
GenomeRNAi-TYRO3 »
Genecards-TYRO3


Protein-protein Interactions for TYRO3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TTLL12 Cat. description Hein, Mann, Cell 2015
Category members IP bait CHRNB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IPPK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LPAR1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM30B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TYRO3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ig-like_dom IPR007110 0.6
Category members Ig_sub IPR003599 0.43
Category members Immunoglobulin IPR013151 0.23
Category members Ig_sub2 IPR003598 0.21
Category members Fibronectin_type3 IPR003961 0.19
Category members Ig_I-set IPR013098 0.13
Category members Ig_V-set IPR013106 0.09
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring TYRO3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TYRO3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0034446 substrate adhesion-dependent cell spreading Database 0.26
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0032940 secretion by cell Database 0.21
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0030168 platelet activation Database 0.13
Category members GO Category GO:0070527 platelet aggregation Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0001779 natural killer cell differentiation Database 0
Category members GO Category GO:0004714 transmembrane receptor protein tyrosine kinase activity Database 0
Category members GO Category GO:0004716 receptor signaling protein tyrosine kinase activity Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0014065 phosphatidylinositol 3-kinase signaling Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0018108 peptidyl-tyrosine phosphorylation Database 0
Category members GO Category GO:0021885 forebrain cell migration Database 0
Category members GO Category GO:0023014 signal transduction by phosphorylation Database 0
Category members GO Category GO:0034122 negative regulation of toll-like receptor signaling pathway Database 0
Category members GO Category GO:0042698 ovulation cycle Database 0
Category members GO Category GO:0043277 apoptotic cell clearance Database 0
Category members GO Category GO:0043491 protein kinase B signaling Database 0
Category members GO Category GO:0043548 phosphatidylinositol 3-kinase binding Database 0
Category members GO Category GO:0045824 negative regulation of innate immune response Database 0
Category members GO Category GO:0050728 negative regulation of inflammatory response Database 0
Category members GO Category GO:0051250 negative regulation of lymphocyte activation Database 0
Category members GO Category GO:0060068 vagina development Database 0
Category members GO Category GO:0070050 neuron cellular homeostasis Database 0


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