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Query: TYMS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TYMS 0 0.226 -1.190 1.570

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TYMS Ubiquitylation K104 -0.543 _ELSSK(gl)GVK_
TYMS Ubiquitylation K169 -0.801 -0.836 _VIDTIK(gl)TNPDDRR_
TYMS Ubiquitylation K99 -0.992 _GSTNAK(gl)ELSSK_

Background Information for TYMS:


Pubmed-TYMS »
Uniprot-TYMS »
Biogrid-TYMS »
ProteomicsDB-TYMS »

Tumorportal-TYMS »
COSMIC-TYMS »
GenomeRNAi-TYMS »
Genecards-TYMS


Protein-protein Interactions for TYMS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARHGEF35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C10orf47 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LIMS1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PKIG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RTN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TYMS
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring TYMS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TYMS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members GO Category GO:0003729 mRNA binding Database 1.38
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0046653 tetrahydrofolate metabolic process Database 0.91
Category members GO Category GO:0042493 response to drug Database 0.66
Category members Pathway Pathway_325 PID_E2F_PATHWAY 0 0.62
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members Pathway Pathway_326 REACTOME_G1_S_SPECIFIC_TRANSCRIPTION 0 0.49
Category members GO Category GO:0048589 developmental growth Database 0.45
Category members Pathway Pathway_332 REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION 0 0.36
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle Database 0.34
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0060574 intestinal epithelial cell maturation Database 0.18
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0032570 response to progesterone Database 0.1
Category members GO Category GO:0045471 response to ethanol Database 0.1
Category members GO Category GO:0048037 cofactor binding Database 0.08
Category members GO Category GO:0006139 nucleobase-containing compound metabolic process Database 0.08
Category members GO Category GO:0046134 pyrimidine nucleoside biosynthetic process Database 0.05
Category members GO Category GO:0051384 response to glucocorticoid Database 0.04
Category members GO Category GO:0051593 response to folic acid Database 0.01
Category members GO Category GO:0031100 organ regeneration Database 0.01
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_278 REACTOME_PYRIMIDINE_METABOLISM 0 0
Category members GO Category GO:0005542 folic acid binding Database 0
Category members GO Category GO:0005976 polysaccharide metabolic process Database 0
Category members GO Category GO:0006206 pyrimidine nucleobase metabolic process Database 0
Category members GO Category GO:0006235 dTTP biosynthetic process Database 0
Category members GO Category GO:0007568 aging Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0008144 drug binding Database 0
Category members GO Category GO:0009636 response to toxic substance Database 0
Category members GO Category GO:0014070 response to organic cyclic compound Database 0
Category members GO Category GO:0019860 uracil metabolic process Database 0
Category members GO Category GO:0033189 response to vitamin A Database 0
Category members GO Category GO:0034097 response to cytokine Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0
Category members GO Category GO:0046683 response to organophosphorus Database 0
Category members GO Category GO:0051216 cartilage development Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0


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