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Query: TXN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TXN 0 -3.190 1.900 -1.090 1.120 0.196 -5.026

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TXN Ubiquitylation K94 0.520 _VGEFSGANK(gl)EK_

Background Information for TXN:


Pubmed-TXN »
Uniprot-TXN »
Biogrid-TXN »
ProteomicsDB-TXN »

Tumorportal-TXN »
COSMIC-TXN »
GenomeRNAi-TXN »
Genecards-TXN


Protein-protein Interactions for TXN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GEMIN5 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait NEDD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNRNP70 Cat. description Hein, Mann, Cell 2015
Category members IP bait TOR1AIP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TXNIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TXN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Thioredoxin_domain IPR013766 0.49
Category members Thioredoxin-like_fold IPR012336 0.16
Category members mRNA_splic_U5 IPR004123 0


Protein complexes (CORUM database) featuring TXN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TXN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0019899 enzyme binding Database 1.57
Category members GO Category GO:0033158 regulation of protein import into nucleus, translocation Database 1.32
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0007267 cell-cell signaling Database 0.94
Category members GO Category GO:0006662 glycerol ether metabolic process Database 0.79
Category members Pathway Pathway_1043 REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS 0 0.78
Category members GO Category GO:0010269 response to selenium ion Database 0.65
Category members Pathway Pathway_1203 REACTOME_INFLAMMASOMES 0 0.5
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members GO Category GO:0030425 dendrite Database 0.26
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0030424 axon Database 0.23
Category members GO Category GO:0046826 negative regulation of protein export from nucleus Database 0.23
Category members GO Category GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway Database 0.21
Category members Pathway Pathway_1204 REACTOME_THE_NLRP3_INFLAMMASOME 0 0.2
Category members GO Category GO:0035690 cellular response to drug Database 0.1
Category members GO Category GO:0009314 response to radiation Database 0.07
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members GO Category GO:0016999 antibiotic metabolic process Database 0.04
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0048678 response to axon injury Database 0.01
Category members Pathway Pathway_1098 PID_P38_MKK3_6PATHWAY 0 0
Category members Pathway Pathway_206 REACTOME_METABOLISM_OF_NUCLEOTIDES 0 0
Category members Pathway Pathway_274 REACTOME_SYNTHESIS_AND_INTERCONVERSION_OF_NUCLEOTIDE_DI_AND_TRIPHOSPHATES 0 0
Category members Pathway Pathway_602 PID_PTP1B_PATHWAY 0 0
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0014823 response to activity Database 0
Category members GO Category GO:0015035 protein disulfide oxidoreductase activity Database 0
Category members GO Category GO:0015949 nucleobase-containing small molecule interconversion Database 0
Category members GO Category GO:0043025 neuronal cell body Database 0
Category members GO Category GO:0043388 positive regulation of DNA binding Database 0
Category members GO Category GO:0055086 nucleobase-containing small molecule metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0071333 cellular response to glucose stimulus Database 0
Category members GO Category GO:0071455 cellular response to hyperoxia Database 0


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