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Query: TRIM21

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TRIM21 0 -0.010 -0.230 -0.010 -0.266 -0.252

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for TRIM21:


Pubmed-TRIM21 »
Uniprot-TRIM21 »
Biogrid-TRIM21 »
ProteomicsDB-TRIM21 »

Tumorportal-TRIM21 »
COSMIC-TRIM21 »
GenomeRNAi-TRIM21 »
Genecards-TRIM21


Protein-protein Interactions for TRIM21
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CSK Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait PFKFB2 Cat. description Hein, Mann, Cell 2015


Protein Domains in TRIM21
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Znf_B-box_chordata IPR020457 0.37
Category members PRY IPR006574 0.17
Category members Znf_B-box IPR000315 0
Category members Znf_RING IPR001841 0
Category members B30.2/SPRY IPR001870 0
Category members Ubox_domain IPR003613 0
Category members SPRY_dom IPR003877 0
Category members Butyrophylin IPR003879 0
Category members ConA-like_lec_gl_sf IPR008985 0
Category members Znf_C3HC4_RING-type IPR018957 0


Protein complexes (CORUM database) featuring TRIM21
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TRIM21
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0030529 ribonucleoprotein complex Database 8.45
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_889 KEGG_SYSTEMIC_LUPUS_ERYTHEMATOSUS 0 0.9
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0000151 ubiquitin ligase complex Database 0.24
Category members GO Category GO:0004842 ubiquitin-protein ligase activity Database 0.24
Category members GO Category GO:0051865 protein autoubiquitination Database 0.18
Category members GO Category GO:0019005 SCF ubiquitin ligase complex Database 0.09
Category members GO Category GO:0000932 cytoplasmic mRNA processing body Database 0.08
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0045787 positive regulation of cell cycle Database 0.04
Category members GO Category GO:0032088 negative regulation of NF-kappaB transcription factor activity Database 0.04
Category members GO Category GO:0032479 regulation of type I interferon production Database 0.04
Category members GO Category GO:0006513 protein monoubiquitination Database 0
Category members GO Category GO:0031648 protein destabilization Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0070206 protein trimerization Database 0


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