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Query: TERF2IP

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TERF2IP 1 1.315 0.500 -0.780 -0.491 1.304 2.217 -1.505 -0.760
TERF2IP 1 1.315 1.450 -1.010 -0.491 1.304 2.217 -1.505 -0.760
TERF2IP 1 1.315 1.580 -0.650 -0.491 1.304 2.217 -1.505 -0.760

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TERF2IP Phosphorylation S157 0.410 _ENARSPSS(ph)VTGNALWK_
TERF2IP Phosphorylation S156 0.369 0.179 _ENARSPS(ph)SVTGNALWK_
TERF2IP Phosphorylation S36 0.199 -0.039 _DDGSSMSFYVRPS(ph)PAK_
TERF2IP Phosphorylation S154 0.255 -0.049 _S(ph)PSSVTGNALWK_
TERF2IP Phosphorylation S203 -0.351 -0.260 _YLLGDAPVS(ph)PSSQK_
TERF2IP Ubiquitylation K228 -0.229 _KAEEDPEAADSGEPQNK(gl)R_

Background Information for TERF2IP:


Pubmed-TERF2IP »
Uniprot-TERF2IP »
Biogrid-TERF2IP »
ProteomicsDB-TERF2IP »

Tumorportal-TERF2IP »
COSMIC-TERF2IP »
GenomeRNAi-TERF2IP »
Genecards-TERF2IP


Protein-protein Interactions for TERF2IP
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DCLRE1B Cat. description Hein, Mann, Cell 2015
Category members IP bait POT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF2IP Cat. description Hein, Mann, Cell 2015
Category members IP bait TINF2 Cat. description Hein, Mann, Cell 2015
Category members IP bait XRCC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ACD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARL4C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARL4D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC106 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FBL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PRPF40A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TADA2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait XAGE1A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TERF2IP
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BRCT_dom IPR001357 1.59
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring TERF2IP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1193 Rap1 complex Database 2.66
Category members Corum 2766 TERF2-RAP1 complex Database 1.52
Category members Corum 1205 TRF2-Rap1 complex III Database 0.24
Category members Corum 1204 Rap1 complex Database 0.04
Category members Corum 1197 TRF1-TIN2 complex Database 0
Category members Corum 1206 TRF-Rap1 complex I, 2MD Database 0
Category members Corum 1207 TRF2-Rap1 complex II Database 0
Category members Corum 138 Telosome complex Database 0


Categories featuring TERF2IP
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000723 telomere maintenance Database 6.3
Category members Pathway Pathway_1312 REACTOME_PACKAGING_OF_TELOMERE_ENDS 0 4.09
Category members Pathway Pathway_328 REACTOME_TELOMERE_MAINTENANCE 0 3.74
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0030870 Mre11 complex Database 1.75
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0007004 telomere maintenance via telomerase Database 0.98
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0032205 negative regulation of telomere maintenance Database 0.23
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members Pathway Pathway_733 ST_G_ALPHA_S_PATHWAY 0 0.13
Category members GO Category GO:0000783 nuclear telomere cap complex Database 0.11
Category members Pathway Pathway_518 ST_G_ALPHA_I_PATHWAY 0 0.05
Category members GO Category GO:0010569 regulation of double-strand break repair via homologous recombination Database 0.01
Category members Pathway Pathway_445 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010833 telomere maintenance via telomere lengthening Database 0
Category members GO Category GO:0031848 protection from non-homologous end joining at telomere Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0
Category members GO Category GO:0051092 positive regulation of NF-kappaB transcription factor activity Database 0
Category members GO Category GO:0070198 protein localization to chromosome, telomeric region Database 0


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